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Sandramycin (ADC-P-137)

ADCs Toxins, The small molecule Rebeccamycin is an indolocarbazole antibiotic, functional as an inhibitor DNA topoisomerase I. The stereochemistry of the pendant sugar on Rebeccamycin is demonstrated to be crucial for the specificity of this DNA interaction. HCT-116: IC50=0,000082 uM; PSN1 : IC50=0,041 uM; T98G : IC50=0,00082 uM; A549 : IC50=0,00041 uM (preliminary laboratory results).
  • CAS NO
  • 100940-65-6
  • Description
  • ADCs Toxins, The small molecule Rebeccamycin is an indolocarbazole antibiotic, functional as an inhibitor DNA topoisomerase I. The stereochemistry of the pendant sugar on Rebeccamycin is demonstrated to be crucial for the specificity of this DNA interaction. HCT-116: IC50=0,000082 uM; PSN1 : IC50=0,041 uM; T98G : IC50=0,00082 uM; A549 : IC50=0,00041 uM (preliminary laboratory results).
  • Classification
  • DNA Inhibitors
  • Molecular Weight
  • 1221.33
  • Purity
  • 95%

For Research Use Only. NOT FOR CLINICAL USE.

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