Anti-CR2 (THB-5)-Mc-MMAF ADC (ADC-W-624)

This ADC product is comprised of an anti-CR2 monoclonal antibody (THB-5) conjugated via a Mc linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

 ADC Target

  • Name
  • CR2
  • Alternative Names
  • CR2; complement component (3d/Epstein Barr virus) receptor 2; CR; C3DR; CD21; CVID7; SLEB9; complement receptor type 2; EBV receptor; complement C3d receptor;
  • Target Entrez Gene ID
  • 1380
  • Overview
  • This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

 ADC Antibody

  • Overview
  • Anti-CR2 IgG2a Antibody, THB-5
  • Generic name
  • THB-5
  • Species Reactivity
  • Mouse

 ADC Linker

  • Name
  • Mc (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

 ADC payload drug

  • Name
  • MMAF (Monomethyl auristatin F)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.


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