NAA Services for Anti-Na⁺/I^- Symporter Antibody

The thyroidal iodide transporters Na⁺/I^- symporter (NIS) have been identified as novel antigens in autoimmune thyroid diseases (AITD). As a leading developer of high-quality immunoassays, Creative Biolabs has accumulated years of experience in the field of AITD diagnosis by taking full advantage of natural autoantibodies (NAA). At present, we are capable to offer a wide range of customized research and analysis services for NIS autoantigen and provide solutions tailored to our customers’ unique specifications.

Background of AntI-Na⁺/I^- Symporter Antibody

Iodide (I^-) is a scarce environmental microelement that is a vital component of thyroid hormone. Cellular uptake of I^- is mediated by NIS, a plasma membrane glycoprotein which transports two Na⁺ ions per each I^- ion and plays a key role in the functioning of the thyroid gland. NIS belongs to the sodium-dependent transporter family 5A. NIS is an integral membrane protein with the amino-terminus facing the extracellular milieu and carboxyl-terminus facing the cytoplasm. The presence of IgG with NIS reactivity suggests that these autoantibodies might affect thyroid function by inhibiting the uptake of I^-, thus playing a role in hypothyroidism.

Fig.1 Schematic model of the human sodium iodide symporter. (Spitzweg, 2002)

The Role of AntI-Na⁺/I^- Symporter Antibody in Thyroiditis

NIS antibodies are present in a proportion of patients with AITD and thus represents an important autoantigen in AITD. Scientists reported that autoantibody against NIS was found in the sera of 84% of patients with Graves' disease (GD) and 12% of patients with Hashimoto's thyroiditis (HT). It is suggested that the incidence of the autoantibodies against NIS is higher in GD than HT, and these antibodies may inhibit I^- uptake.

Fig.2 Clinical implications of NIS. (Spitzweg, 2002)

What We Can Do about NAA?

Equipped with well-established platforms and experienced scientists, Creative Biolabs can provide a whole set of services for the detection and profiling of NIS autoantibodies. In addition, we also provide other NAA services, such as the detection of autoantibodies repertoire, the discovery of novel tumor markers, the development of disease diagnosis, etc. A wide spectrum of NAA products is also available for your choice.

Features of Our AntI-Na⁺/I^- Symporter Services Including But Not Limited to:

Diverse immunological detection approach with high accuracy
Shorter turnaround times to ensure your project progress
Cost-effective to make sure your budget is manageable
Best after-sale service

Antibodies against the NIS have been found in adult patients with AITD and its evaluation is of great value for thyroiditis diagnosis and treatment. Creative Biolabs is an undisputed global leader in the custom disease diagnosis and provides analysis services for various biomarkers for a wide variety of diseases. In addition to NIS marker, we are also professional in providing autoantibodies detection services against other biomarkers towards thyroiditis to improve the performance of diagnostic tests. If you are interested in our services, please feel free to contact us for more information.

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