- Home
- Products
- Customized ADCs
- ITIH4
- Anti-ITIH4-Mc-VC-PABC-MMAE ADC
Anti-ITIH4-Mc-VC-PABC-MMAE ADC (CAT#: ADC-W-228)
This ADC product is comprised of an anti-gp120 monoclonal antibody conjugated via a Mc-VC-PABC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- ITIH4
- Alternative Names
- H4P; IHRP; GP120; PK120; ITIHL1; PK-120; ITI-HC4
- Target Entrez Gene ID
- 3700
- Target UniProt ID
- Q14624
- Overview
- The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene.
- Overview
- Anti-ITIH4 IgG1 Antibody
- Species Reactivity
- Mouse
- Name
- MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Name
- MMAE (Monomethyl auristatin E)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-FOLR1 (Farletuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-1171)
- Anti-IL1B-MC-Vc-PAB-SN38 ADC-1 (CAT#: ADC-W-1338)
- Anti-IL6 (Enlimomab)-SPDB-DM4 ADC (CAT#: ADC-W-2247)
- Anti-PVRL4-MC-MMAF ADC (CAT#: ADC-W-2398)
- Anti-ITGA4+ITGB7 (Crenezumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-2501)
- Anti-HBV surface antigen (Libivirumab)-SMCC-DM1 ADC (CAT#: ADC-W-1970)
- Anti-EpCAM-hydrazone-Doxorubicin ADC-2 (CAT#: ADC-W-581)
- Anti-CD5 (Zolimomab aritox)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-931)
- Anti-S. epidermidis LTA (Pagibaximab)-SMCC-DM1 ADC (CAT#: ADC-W-2258)
- Anti-CEACAM6 (Sulesomab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-979)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-228. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-227 | Anti-ITIH4-MCC-DM1 ADC | MCC (Maleimidomethyl cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-229 | Anti-ITIH4-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-226 | Anti-ITIH4-SPP-DM1 ADC | SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-532 | Anti-ITGAE-Mc-VC-PABC-MMAE ADC-1 | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE (Monomethyl auristatin E) |
| ADC-W-611 | Anti-CD72-Mc-VC-PABC-MMAE ADC | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE (Monomethyl auristatin E) |
| ADC-W-451 | Anti-CD70-Mc-VC-PABC-MMAF ADC-1 | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-616 | Anti-CD19-Mc-MMAF ADC-5 | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-615 | Anti-CD19-Mc-VC-PABC-MMAE ADC-5 | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-021 | anti-MIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-W-499 | Anti-SLC34A2 (Lifastuzumab)-VC-MMAE ADC | mc-VC-PABC | MMAE (Monomethyl auristatin E) |
| ADC-AA-048 | Protein G-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-029 | anti-MIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-W-462 | Anti-GPNMB-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
