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Arcitumomab-OGreen (CAT#: ADC-FL-935)

This product is comprised of an anti-CEACAM1 Fab' fragment (Arcitumomab) labeled with Oregon green. Oregon green is a green-fluorescent dye and it's excitation/emission is 501/526 nm.

  • TARGET
  • ANTIBODY
  • DYE
  • Name
  • CEACAM1
  • Alternative Names
  • CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); BGP; carcinoembryonic antigen-related cell adhesion molecule 1; BGP1; CD66a; antigen CD66; CD66a antigen; BGPI;
  • Overview
  • This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
  • Overview
  • Humanized Anti-CEACAM1 IgG1-Fab’ fragment, Arcitumomab
  • Generic name
  • Arcitumomab
  • Species Reactivity
  • Human
  • Name
  • Oregon green
  • Color
  • Green
  • Excitation⁄Emission (nm)
  • 501/526

For Research Use Only. NOT FOR CLINICAL USE.

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ADC-W-966 Anti-CEACAM1 (Arcitumomab)-MC-Vc-PAB-SN38 ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin)
ADC-W-963 Anti-CEACAM1 (Arcitumomab)-SPDB-DM4 ADC SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
ADC-W-962 Anti-CEACAM1 (Arcitumomab)-SMCC-DM1 ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-964 Anti-CEACAM1 (Arcitumomab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-965 Anti-CEACAM1 (Arcitumomab)-MC-Vc-PAB-MMAE ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE

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