Anti-TACSTD2 (clone C16)-PEG6-Aur3377 ADC (ADC-W-539)

This ADC product is comprised of an anti-TACSTD2 monoclonal antibody (clone C16) conjugated via a PEG6 linker to Aur3377. The Aur3377 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, Aur3377 binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
  • Antibody clone #
  • C16

 ADC Target

  • Name
  • TACSTD2
  • Alternative Names
  • TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic ca
  • Target Entrez Gene ID
  • 4070
  • Overview
  • This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.

 ADC Antibody

  • Overview
  • Anti-TACSTD2 Antibody, clone # C16
  • Clone #
  • C16
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • Amino-PEG6-based linker

 ADC payload drug

  • Name
  • Aur3377
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.


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