ADC Linker Products

Product Overview Related Services Scientific Resources Quick Links Product List

Product Overview

Creative Biolabs offers a variety of chemically versatile linker molecules to facilitate antibody-drug conjugate (ADC) development projects. All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC. Creative Biolabs carries a series of cleavable linkers (pH-sensitive linkers, disulfide linker, peptide linkers, β-glucuronide linkers), non-cleavable linkers, and intermediate linker modules. In the meantime, we also offer the services in the DrugLnk synthesis platform to prepare customized linkers with unique structures.

ADC Linker Services

Creative Biolabs offers a comprehensive "DrugLnk" linker module designed to cater to the diverse needs of antibody-drug conjugate (ADC) development. This module focuses on the design and preparation of various types of linkers, tailored to their specific drug release mechanisms. Clients can choose from a range of linker types:

Leveraging an advanced synthetic chemistry platform along with an extensive inventory of toxins, linkers, and drug-linker sets, "DrugLnk" at Creative Biolabs enables our skilled chemists to provide specialized services.

(1) Design linkers with optimal size
(2) Select linkers with suitable release mechanism
(3) Engineer linkers with compatible conjugation chemistry
(4) Synthesize customized linkers
(5) Modify payload drug
(6) Design synthesis routes
(7) Synthesize customized drug-linker complexes

Please feel free to contact us for more information about our ADC linker services.

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

Global Antibody-drug Conjugate (ADC) Clinical Trial ReviewGlobal Antibody-drug Conjugate (ADC) Clinical Trial Review 2018.3

Creative Biolabs ADC Product Brochure

Protocol

Quick Links

ADC Toxins

Drug-linker Complexes

Customized ADCs

Anti-Ab ADCs

Product List

Catalog	Product name	CAS NO	Structure	Molecular Weight	Purity	Data sheet	Inquiry
ADC-L-501	Methyl-PEG3-Sulfone-PEG4-alkyne	2055041-02-4		426.5	95%		Inquiry
ADC-L-502	Methyl-PEG3-Sulfone-PEG3-t-butyl ester	2055041-00-2		472.6	95%		Inquiry
ADC-L-503	Alkyne-PEG4-Sulfone-PEG4-acid	2055024-41-2		528.6	95%		Inquiry
ADC-L-504	Alkyne-PEG3-Sulfone-PEG3-alkyne	2055024-44-5		494.6	95%		Inquiry
ADC-L-505	Alkyne-PEG4-Sulfone-PEG4-t-butyl ester	2055024-43-4		584.7	95%		Inquiry
ADC-L-506	t-Butyloxycarbonyl-PEG4-Sulfone-PEG4-t-butyl ester			674.9	95%		Inquiry
ADC-L-507	endo-BCN-PEG2-acid	1993134-72-7		353.4	95%		Inquiry
ADC-L-508	endo-BCN-PEG2-NHS ester	2243565-12-8		450.5	95%		Inquiry
ADC-L-510	endo-BCN-PEG4-t-butyl ester	1807501-83-2		497.6	95%		Inquiry
ADC-L-511	endo-BCN-PEG2-alcohol	1807501-85-4		325.4	95%		Inquiry
ADC-L-512	endo-BCN-PEG3-Boc-amine	1807501-84-3		468.6	95%		Inquiry
ADC-L-514	DNP-PEG4-NHS ester	858126-78-0		528.5	95%		Inquiry
ADC-L-515	DNP-PEG4-t-butyl ester	1817735-31-1		487.5	95%		Inquiry
ADC-L-516	DNP-PEG3-N3	951671-87-7		384.4	95%		Inquiry
ADC-L-517	DNP-PEG4-alcohol	1807520-99-5		359.3	95%		Inquiry
ADC-L-518	DNP-PEG4-DBCO			689.7	95%		Inquiry
ADC-L-519	DNP-PEG3-DNP	1365655-92-0		524.4	95%		Inquiry
ADC-L-520	m-PEG3-aldehyde	356066-46-1		176.2	95%		Inquiry
ADC-L-521	m-PEG4-benzaldehyde	153364-63-7		268.3	95%		Inquiry
ADC-L-522	Ald-Ph-PEG2-acid	1807534-84-4		309.3	95%		Inquiry