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Anti-CD70 (clone h1F6239C)-PBD ADC (ADC-W-573)

This ADC product is comprised of an anti-CD70 monoclonal antibody (clone h1F6239C) conjugated via a linker to PDB. The PDB is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, PDB binds to DNA, causes DNA damage.
  • Antibody clone #
  • h1F6239C

 ADC Target

  • Name
  • CD70
  • Alternative Names
  • CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
  • Target Entrez Gene ID
  • 970
  • Overview
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

 ADC Antibody

  • Overview
  • Anti-CD70 Antibody, clone # h1F6239C
  • Clone #
  • h1F6239C
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • maleimidocaproyl-valine-alanine

 ADC payload drug

  • Name
  • pyrrolobenzodiazepine (PBD)
  • Description
  • Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

For Research Use Only. NOT FOR CLINICAL USE.

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