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Anti-BSG (Ziralimumab)-MC-MMAF ADC (CAT#: ADC-W-724)

This ADC product is comprised of an anti-BSG monoclonal antibody conjugated via a MC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • BSG
  • Alternative Names
  • BSG; basigin (Ok blood group); basigin (OK blood group) , OK; basigin; CD147; EMMPRIN; CD147 antigen; OK blood group antigen; collagenase stimulatory factor; leukocyte activation antigen M6; extracellular matrix metalloproteinase inducer; tumor cell-deriv
  • Target Entrez Gene ID
  • 682
  • Overview
  • The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Overview
  • Human Anti-BSG IgM antibody, Ziralimumab
  • Generic name
  • Ziralimumab
  • Host animal
  • Human
  • Species Reactivity
  • Human
  • Name
  • MC (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Name
  • MMAF
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
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CAMouse™-Fully Human Antibody Generation Platform
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CAT# Product Name Linker Payload
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ADC-W-2606 Anti-ITGB3 (Tadocizumab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF

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