Body Fluid-derived Exosome Isolation and Development Services
Body fluids are biologically rich samples that provide valuable insights into health status, disease mechanisms, and therapeutic potential through the analysis of their exosome (Exo) content. Creative Biolabs offers body fluid-derived exosome (BF-Exo) extraction and development services to support biomedical research and clinical applications, thereby advancing the understanding of disease diagnostics, treatment, and mechanisms.
BF-Exos: A Heterogeneous Collection
BF-Exos refer to a heterogeneous collection of extracellular vesicles secreted by various cell types present in body fluids such as blood, urine, saliva, cerebrospinal fluid, and more. These Exos are released from source cells and disseminate through the fluid circulation to other cells and tissues, playing a crucial role in cell communication, information transfer, and signal regulation.
Fig.1 Tissue- -derived extracellular vesicles are found in tissue interstitium released from various types of cells.2
Common BF-Exos
Blood (Plasma/Serum)-Derived Exos
Blood plasma-derived Exos are preferred for research as they better preserve Exo integrity and avoid interference from platelet release. Serum-derived Exos might be more suitable for diseases related to platelets.
Urine-Derived Exos
Exos from urine predominantly originate from various cell types in the urinary tract system, aiding in early diagnosis and monitoring of urinary system diseases.
Saliva-Derived Exos
Exos from saliva contain information from oral and gastrointestinal cell secretions, facilitating research in oral health and digestive tract diseases.
Cerebrospinal Fluid (CSF)-Derived Exos
CSF-derived Exos offer insights into neurological health and diseases, particularly valuable for studying neurodegenerative disorders.
Amniotic Fluid-Derived Exos
The biomolecules in amniotic fluid-derived Exos might relate to fetal development and maternal health, holding potential for pregnancy-related disease research.
Tissue Intercellular Fluid-Derived Exos
These originate from diverse cell types within specific tissues and are used for studying tissue-specific signaling pathways, combined Exo tracing with single-cell sequencing, and inter-tissue communication mechanisms.
Breast Milk-Derived Exos
These are predominantly from mammary gland cells of mammals. Exos from sources like cow's milk have sparked research interest for drug delivery and skin improvement studies.
BF-Exo Development Services at Creative Biolabs
Studying Exos in body fluids provides information about cell states, health conditions, and disease processes. Analyzing BF-Exos can uncover potential biomarkers for early disease diagnosis, prognosis assessment, and therapeutic target development. This research field holds broad applications in biomedical research and clinical practice. Creative Biolabs offers services to isolate and characterize Exos from various body fluid samples.
1. Exo Isolation and Purification
We provide services to isolate and purify Exos from different body fluid sources. This includes optimizing sample processing, centrifugation, and separation steps to obtain high-quality Exo samples.
2. Exo Analysis and Identification
We perform analyses and identification of exosomal components such as proteins, nucleic acids, lipids and metabolites for understanding their composition and characteristics.
3. Biomarker Research
We offer in-depth profiling services of Exos to help identify potential Exo biomarkers
4. Biomarker Tracing Studies
We provide emerging single-cell and Exo co-study services and tissue-derived Exo-related services to further identify the source cells of key biomarkers in fluid-derived Exos.
5. Specific Exo Subsets
We offer immune-affinity Exo subset capture services based on specific antigens on Exos for more precise research.
Restricted BF-Exo Development
In certain cases, some body fluid samples may carry potential infectious risks, which might lead to transportation restrictions or non-acceptance by us. In such situations, opting to purchase products developed by Creative Biolabs is a reasonable choice.
Creative Biolabs are backed by exceptional expertise and extensive experience, providing high-quality BF-Exo research solutions to uncover valuable information within fluid samples. If you're seeking an efficient and reliable platform for BF-Exo research, please contact us.
Reference
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Li, SR.; Man, QW.; et al. Tissue-derived extracellular vesicles in cancers and non-cancer diseases: present and future. Journal of Extracellular Vesicles. 2021. 10(14):e12175.
For Research Use Only. Cannot be used by patients.
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