Exosome In Vivo Functional Research Services
Overview Services Features FAQs
Overview
Exosomes are a type of extracellular vesicles (EVs) secreted by various cells into the extracellular fluids. They are endogenous nanoparticles with a diameter ranging from 30 to 100nm and thus bypass elimination due to macrophages and neutrophils and show enhanced permeability and retention (EPR) effect termed as passive targeting. The vital role played by exosomes during physiological and pathological conditions has opened up remarkable opportunities for researchers in exosome-based drug delivery. Exosomes might serve as an effective drug carrier for disease treatment, superior to synthetic polymeric and lipidic nanoparticles which are associated with the high cost of production, reproducibility issue, toxicity, and triggering of the immune response. However, application of exosomes in site-specific drug delivery requires modification of the exosome surface by attaching a targeting ligand to reach the intended site of action and/or an imaging molecule for tracking exosomes and determining their biodistribution.
Services
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Exosome Labeling and Imaging Services for In Vivo Functional Research
Exosomes can be labeled for imaging in two primary ways: exogenously and endogenously. Exogenously labeled exosomes are created by first extracting them from cell culture medium using an suitable exosome extraction technique, then decorating their surface with a fluorescent dye. Endogenously labeled exosomes, on the other hand, are produced by genetically engineering exosome-producing cells with viral vectors that express genes for BFP, (E)GFP, or mCherry.
The choice of imaging methods, such as in vivo imaging systems or microscopy, depends on the labeling technique used and the specific objectives of each study. Optical imaging is a widely employed technique for tracking or studying the biodistribution of exosomes. Each imaging technique has its own unique advantages, which can serve as criteria for selecting the most suitable labeling method based on the intended purpose of exosome tracking or imaging.
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In Vivo Model Construction and Application Services
Exosomal function researches by in vivo models are usually the most intuitive way. Focusing on exosome function research over years, Creative Biolabs has accumulated extensive experience and has established our own exosome function research in vivo model's platform. Disease models construction service we can product include, but are not limited to:
In addition, we can also provide the most suitable exosome administration mode according to your needs.
Features
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Advanced exosome labeling technology
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Extensive range of animal models
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Comprehensive in vivo studies
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One-stop exosome service platform
If you looking for a partner in exosome in vivo function research or you have any other questions about our services, please feel free to contact us for more information.
FAQs
Q: What is exosome labeling, and why is it important?
A: Exosome labeling involves attaching detectable markers, such as fluorescent proteins, to exosomes, enabling researchers to track and study their distribution and behavior in vivo. This is crucial for understanding exosome-mediated communication, therapeutic potential, and biodistribution in different biological systems.
Q: What animal models do you use for in vivo exosome functional studies?
A: We utilize a variety of animal models, including rodents, to study exosome biodistribution, therapeutic efficacy, and mechanistic pathways in vivo. Our models are selected based on the specific requirements of each research project.
Q: Can you customize the exosome labeling and in vivo study services to fit specific research needs?
A: Yes, our technical team will design a customized experimental plan based on the in-depth communication and demand analysis with customers in the early stage, combined with the specific goals and requirements of the project. In addition, we will make real-time adjustments and optimizations according to various problems that may arise during the experiment, striving to provide customers with the most valuable experimental data and promote the successful implementation and sustainable development of the project.
For Research Use Only. Cannot be used by patients.
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