Due to their native structural property and functions in cell-cell communication, exosomes have the potential to be used as a carrier of gene and drug delivery for clinical applications. As a professional research institute and years of experienced supplier in biotech markets, Creative Biolabs devotes to offering high-level and cost-efficient customized exosome services for further understanding of exosome structure and biogenesis. Aided by our exosome engineering platforms and accurate results, researchers can rapidly and extensively refresh molecular mechanisms of exosome functions and expand insights into their practical potency.

Exosome Engineering

The capacity of exosomes to employ as biovesicles for proteins, lipids, and nucleic acids, and their role in intercellular communication, make them a powerful platform for biomarker discovery and drug delivery. Therapeutically, exosomes have been used in a variety of forms. They are inherently bioactive so that can be isolated from cells for downstream use without further modification.

For example, exosomes extracted from mesenchymal stem cells (MSC), significantly reduce the damaged tissue area after myocardial infarction in mice with induced heart attacks. Besides applications in native states, the properties and biogenesis of exosomes also make them easy to modification, allowing scientists to specifically customize exosomes to particular applications. Alvarez-Erviti group was the first to enrich exosomes with siRNAs and genetically equip them with neuron-specific rabies virus glycoprotein peptides to target the brain. They were able to silence 60% expression of beta-secretase 1 (BACE-1) gene, a critical player in the progression of Alzheimer. Since then, numerous studies have reported the use of exosomes for the treatment in diverse diseases, such as in oncology, neurology, ischemic diseases, liver disease, immune disorders, and therapeutic vaccination.

Consideration of extracellular vesicles (EVs) in the design stage of tissue engineering approaches. Fig 1. Consideration of extracellular vesicles (EVs) in the design stage of tissue engineering approaches. (Lamichhane, 2015)

Exosome Engineering Services in Creative Biolabs

Exosomes comprise a heterogeneous population of cell-derived lipid vesicles, and have emerged as mediators of intercellular information transport in many biological systems and vehicles for drug delivery. In both roles, exosomes have great potential to impact tissue engineering and regenerative medicine.

Proposed model of exosomal composition and subpopulations. Fig.2 Proposed model of exosomal composition and subpopulations. (Ferguson, 2016)

Harnessing exosome engineering in therapeutic drug vehicles requires a better understanding of exosomal compositions and their mode of activities. In Creative Biolabs, using systemic exosome analytical technologies, a full appreciation of exosomal contents of proteins, lipids, and RNA molecules will be delineated for the design of effective exosome-based or exosome-mimicking drug carriers. Remarkably, there are several cutting-edge systems for exosomes engineering that have been devised to achieve particular projects in clients’ requirements.

No matter exosome profiling, drug vehicles, or biomarker discovery, Creative Biolabs can make use of easy-to-access exosome engineering techniques to acquire physiological information of parental cells, or in-depth studying exosome biology. Our customized services have strong capability to provide comprehensive technical support that involves a pre-service consultation and all date from exosome isolation to purification, analysis, and interpretation. If there is no option for exosome services you're interested, please contact us by email with your special needs.

References:

  1. Kourembanas, S.; et al. Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu Rev Physiol. 2015, 77: 13-27.
  2. Lamichhane, T.N.; et al. Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine. Tissue Eng Part B Rev. 2015, 21(1): 45-54.
  3. Ferguson, S.W.; Nguyen, J. Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity. J Control Release. 2016, 228: 179-190.

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