NAA Services for Anti-C Antibody

Genotyping is extremely important in determining the suitable blood groups of polytransfused patients with β-thalassemia, and it assists in the identification of suspected alloantibodies and the selection of antigen-negative red blood cells (RBCs) for transfusion. Creative Biolabs has a professional team and advanced laboratory equipment to provide natural autoantibody (NAA) services. Based on clients' requirements, there are a series of anti-C services can be offered to assist studies on C antigen.

Background of Anti-C Antibody

There are six common types of Rh antigens in human beings, designated as C, D, E, c, d, and e. The proteins which carry the Rh antigens are transmembrane proteins, whose structure suggest their functions as ion channels. The main antigens are D, C, E, c, and e, which are encoded by two adjacent gene loci. The RHD gene encodes the RhD protein with the D antigen (and its variants) and the RHCE gene encodes the RhCE protein with the C, E, c, e antigens (and their variants). The Rh system is considered to be the most important blood group system after ABO. Antibodies against Rh antigens are known to cause hemolytic disease. From a clinical point of view, identification of anti-C autoantibody is useful in giving transfusion support with C antigen negative blood. Additionally, studies confirmed that anti-C autoantibody together with anti-D autoantibody resulted in significant morbidity in newborns hemolysis.

Fig.1 Model of topology for RhAG, RhCE, and RhD. (Avent, 2000)

The Role of Anti-C Antibody in Thalassemia

Many different blood group systems, such as Rh, ABO, Kell, Kidd, Duffy, MNS, have been reported as causes of hemolytic disease. Thalassemia is one of the most common monogenic disorders characterized by reduced production of globin chains. Although regular RBC transfusion support is the main treatment for thalassemia patients, it may be associated with complications such as RBC alloimmunization. Numerous cases reported that among patients with thalassemia, the most common autoantibody was anti-K, followed by anti-D, anti-C, anti-E. The irregular antibody production in β-thalassemic children with long-term transfusion may have some relevance with Rh factor genotypes and thalassemia genetic mutations.

Fig.2 Current and future therapies for β-thalassemia major. (de Dreuzy, 2016)

What We Can Do About NAA?

At Creative Biolabs, we can offer NAA services to cover every step of your NAA project. Our custom services include NAA detection, NAA profiling, NAA epitope mapping, etc. Our autoantibody microarray platform can quickly and efficiently detect the autoantibody library with high accuracy and sensitivity. A wide spectrum of NAA products is also available for your choice.

Antibody production against RBC antigens makes a hard condition in regular blood transfusion and double antibodies production may complicate this situation. Thus, it is advisable to type patients and match the red cells in multiply transfused thalassemia patients. Equipped with extensive experience and advanced platform, talented scientists at Creative Biolabs provide you with a comprehensive set of services towards anti-C antibody. If the target you interested in not mentioned above, please don’t hesitate to contact us for more information.

References:

Avent, N.D.; Reid, M.E. The Rh blood group system: a review. Blood. 2000, 95(2): 375-387.
de Dreuzy, E.; et al. Current and future alternative therapies for beta-thalassemia major. Biomedical journal.2016, 39(1): 24-38.

For Research Use Only | Not For Clinical Use

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