CAR Targeting Carcinoma-specific Antigens

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

As a leading and reliable service provider, Creative Biolabs is well known worldwide for its breakthrough in CAR production system. Based on targeting carcinoma-specific antigens in the follow table, our outstanding scientists have constructed diverse CAR-T cells or CAR NK cells targeting these antigens. In addition to these, Creative Biolabs can also customize CAR product according to your special requirements.

CAR Targeting Carcinoma-specific Antigens Vicki Brower. The CAR T-Cell Race. The scientist. 2015

As a group of cancer, carcinoma usually starts from skin and spreads to other organs of the body. It accounts for 90% of all cancers, which mostly occurs in adults, with the DNA mutation as its main cause. Based on the tissue which cancer cells arise from, the primary carcinoma category includes breast cancer, prostate cancer, colorectal cancer, lung malignancy, adenocarcinomas, cervical carcinoma, melanoma and renal cell carcinoma. The most common symptom is lump under the skin, while there're some other symptoms such as skin discolorations, pains. Although few strategies show effectiveness in carcinoma treatment, immunotherapy has performed great potential as a promising approach to treat carcinoma, such as CAR modified T cells or natural killer (NK) cells. Experts from Creative Biolabs can offer various CAR-T cell or NK cells construction services according to your request.

Based on a great amount of experiments, we are confident our first-class CAR products can greatly accelerate your project process. Please feel free to contact us at any time.

Products against Carcinoma-specific antigens

Associated malignancy	Target antigen	Receptor type	Product
Renal cell carcinoma (RCC)	Carbonic anhydrase IX (CAIX)	scFv-CD28-41BB-CD3ζ	CAR-MZ204
	CSPG4	scFv-CD28-CD3ζ	CAR-LC134
	G250 epitope	iRGD-scFv-CD28-41BB-CD3ζ	CAR-LC371
	VEGFR-2	scFv-CD28-41BB-CD3ζ	CAR-LC132
	VEGFR-2	scFv-CD28-CD3ζ	CAR-LC133
Melanoma	EGFR	scFv-CD3ζ	CAR-LC097
		scFv-CD28-CD3ζ	CAR-LC098
		scFv-CD28-41BB-CD3ζ	CAR-LC100
	Trop2	scFv-CD28-41BB-CD3ζ	CAR-LC190
	PD-L1	PD1-41BB-CD3ζ	CAR-LC282
	Cs-1	scFv (SLAMF7)-CD28-41BB-CD3ζ/scFv (FN)-cMYCmu	CAR-LC365
	BCMA	scFv-CD28-41BB-CD3ζ	CAR-T-3-L335-2BZ
	CS1	scFv-CD28-OX40-CD3ζ	CAR-NK-3-M329-2XZ
	CSH1	scFv-CD28-41BB-CD3ζ	CAR-T-3-L349-2BZ
	HMW-MAA	scFv-CD28-41BB-CD3ζ	CAR-T-3-M318-2BZ
	NY-ESO-1	scFv-CD28-41BB-CD3ζ	CAR-T-3-M323-2BZ
	GD3	scFv-CD28-41BB-CD3ζ	CAR-T-3-M317-2BZ
	MART-1(DMF5)	scFv-CD28-41BB-CD3ζ	CAR-T-3-M310-2BZ
	CD56	scFv-CD28-41BB-CD3ζ	CAR-T-3-M312-2BZ
	gp100	VHH-41BB-CD3ζ	CAR-T-2-M552-BZ
Lung malignancy	Mesothelin	scFv-CD28-41BB-CD3ζ	CAR-LC054
		scFv-CD3ζ	CAR-LC023
		scFv-CD28-CD3ζ	CAR-LC024
	ALK	scFv-CD28-41BB-CD3ζ	CAR-LC103
	Fibroblast activation protein (FAP)	scFv-41BB-CD3ζ	CAR-LC224
	CD87	scFv-41BB-CD3ζ-IL12	CAR-LC265
	Tissue factor	Protein-41BB-CD3ζ	CAR-LC288
	TF	scFv-CD28-OX40-CD3ζ	CAR-T-3-L406-2XZ
Colorectal cancer	CEA	scFv-CD28-41BB-CD3ζ	CAR-T-3-M314-2BZ
	EGP-2	scFv-CD28-41BB-CD3ζ	CAR-T-3-M316-2BZ
	TAG-72	scFv-CD28-41BB-CD3ζ	CAR-T-3-M325-2BZ
	CD276	scFv-CD28-CD3ζ	CAR-LC162
	EpCAM	scFv-CD28-41BB-CD3ζ	CAR-LC181
	HLA-A2-WT1DB126	scFv-CD28-FcγR1γ	CAR-LC266
Prostate cancer	PSMA	scFv-CD28-OX40-CD3ζ	CAR-T-3-L336-2XZ
Prostate cancer	PSCA	scFv-CD28-CD3ζ	CAR-MZ157
Breast cancer	CD8	scFv-CD28-41BB-CD3ζ	CAR-T-3-L348-2BZ
	ErbB2	scFv-CD28-41BB-CD3ζ	CAR-T-3-L337-2BZ
	MUC1	scFv-CD28-41BB-CD3ζ	CAR-T-3-M322-2BZ
	TEM8	scFv-CD28-41BB-CD3ζ	CAR-T-3-L343-2BZ
	SSEA4	scFv-41BB-CD3ζ	CAR-LC001
	CD33	scFv-CD28-CD3ζ	CAR-LC155
	HER2	scFv-41BB-CD3ζ	CAR-LC172
	NY-BR-1	scFv-CD28-41BB-CD3ζ	CAR-LC220
	CD44	scFv-CD28-CD3ζ	CAR-LC226
	CD47	scFv (CD47)-CD28-41BB-CD3ζ/scFv (TAZ)-TET2	CAR-LC364