Exosomes, small membrane vesicles (30-150 nm) of endocytic origin secreted by most cell types, contain functional biomolecules, which can be horizontally transferred to recipient cell. Exosomes bear a specific protein and lipid composition, and carry a select set of functional mRNAs and microRNAs. Recent study has shown that c-Met shed in exosomes can promote a proangiogenic and prometastatic phenotype in bone marrow-derived progenitor cells during melanoma progression. Exosome DNA fragments can serve as disease biomarkers, making their effective identification particularly important. Exosome DNA extraction kit provided by Creative Biolabs can extract exosomal DNA from various sources such as serum, plasma, or other bodily fluids.