Antisense Oligonucleotides (ASOs)

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Antisense Oligonucleotides (ASOs) Products for Familial Hypercholesterolemia


Familial hypercholesterolemia (FH) is an inherited disorder that causes high cholesterol levels, specifically low-density lipoprotein (LDL). Antisense oligonucleotide therapy is a promising approach for the treatment of familial hypercholesterolemia and functions at the cellular level by leading to degradation of specifically targeted abnormal gene products implicated in the disease process. Such as the Mipomersen, a novel antisense oligonucleotide injectable drug, has been approved for the treatment of familial hypercholesterolemia, which is complementary in sequence to a segment of the human apolipoprotein (Apo) B-100 messenger RNA, the primary apolipoprotein associated with low-density lipoprotein cholesterol (LDL-C). Through the specific binding, the ASOs block translation of the gene product, consequently decreasing the hepatic production of LDL.

 Antisense-Oligonucleotides-(ASOs)-Products-for-Familial-Hypercholesterolemia-1

Creative Biolabs is a world-renowned service provider for antisense oligonucleotides therapy development. We provide a variety of top-quality ASO products for familial hypercholesterolemia therapy. A series of stringent criteria are applied to implement quality control of antisense products in order to guarantee reliability. We are dedicated to providing the best-characterized antisense therapy service to help our customers to expedite their project application. Please feel free to contact us by e-mail for a quote and more technical support.

Reference

  1. Collin, R. and Garanto, A. (2017). Applications of antisense oligonucleotides for the treatment of inherited retinal diseases. Current Opinion in Ophthalmology. 28(3), pp.260-266.

For Lab Research Use Only, Not for Human or Animal Therapeutic Use.

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