Antisense Oligonucleotides (ASOs)
Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded deoxyribonucleotides, which bind to target RNA with base-pair complementarity and exert various effects based on their chemical structure and design. There are three underlying mechanisms to modulate RNA function, including mRNA target degradation via recruitment of the RNase H enzyme, alternative splicing modification to include or exclude exons, and miRNA inhibition to inhibit miRNA binding to its target mRNA. Equipped with the advanced platform, Creative Biolabs has the expertise and ability in providing high-quality and abundant ASO products to meet different research demands of worldwide clients.
Figure 1. Common ASOs mechanisms of action (Schoch, 2017)
As one of the leading biotechnology companies in the world, Creative Biolabs has sophisticated equipment and highly experienced staff. Scientists at Creative Biolabs are able to provide you with custom antisense oligonucleotide synthesis services. We also offer a series of ready-to-use ASO products for various disease research, including cancer, cytomegalovirus retinitis, familial hypercholesterolemia, viral hemorrhagic fever, HIV/AIDS, spinal muscular atrophy, Duchenne muscular, hypertriglyceridemia and other human diseases. Please feel free to contact us to learn more about our capabilities and products.
Features of Our Custom Antisense Oligonucleotide Products
- High-quality and cost-effective
- Comprehensive backbones and modifications
- Flexible synthesis scales and bulk orders are available upon request
- Cover a range of targets for different human diseases
Featured ASOs Products for Different Indications
We also offer custom antisense oligonucleotides synthesis in ready-to-use duplex multi-scale quantities for your project development.
Reference
- Schoch, K. and Miller, T. (2017). Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases. Neuron. 94(6), pp.1056-1070.
