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Development of Bacteria as Gene Delivery System

Novel viral and non-viral transport vehicles bring dawn to the development of gene therapy by increasing the efficiency of transfection. Bacteria become an attractive gene delivery vector because it can transfer therapeutic gene product into the target organism, organ or tissue directly. Creative Biolabs provides the state-of-the-art non-viral vector technology for basic research and preclinical applications.

Bacteria used for gene therapy

Bactofection is a promising technique for transfection in human gene therapy. Transformed bacteria that contain plasmids carrying the transgene are applicated into the target tissue, then vectors can release plasmids to express therapeutic transgene through undergo lysis. Bactofection can also be used for DNA vaccination against numerous microbial agents. Specific dsRNA production can be delivered into the target cells via bactofection to achieve RNA interference. We offer various attenuated bacteria strains and the use of antibiotics in bactofection to reduce the risk of clinically symptomatic infections to minimum without affecting the expression of therapeutic genes.

The mechanism of BactofectionFig.1 The mechanism of Bactofection

Bacterial strains

Using bactofection in various disease modelsFig.2 Using bactofection in various disease models

Alternative gene therapy

Alternative gene therapy (AGT) is a therapeutic method that the gene is not transferred into the host cells but the produced protein catalyzes the conversion of an exogenously applied harmless molecule into an agent with detrimental effects on tumor tissue. S. typhimurium and C. sporogenes can be used to deliver cytosine deaminase (CD) in the therapy of colorectal cancer, spleen cancer and various lymphatic tumors. And B. longum transformed with human endostatin has been used for the treatment of liver tumors. The side effects of this kind of chemotherapy are limited by the tissue-specific growth and expression.


With a skilled team of scientists, Creative Biolabs provides cutting-edge bactofection method and various modified bacterial strains for basic research and preclinical applications. Please feel free to contact us for more details and we are pleased to offer you the best services.


  1. Palffy, R.; et al. (2006). Bacteria in gene therapy: bactofection versus alternative gene therapy. Gene therapy, 13(2), 101.

For Lab Research Use Only, Not for Human or Animal Therapeutic Use.

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For Lab Research Use Only, Not for Human or Animal Therapeutic Use.

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