Small Interfering RNA (siRNA)
Upon the discovery of RNA interference (RNAi), small interfering RNA (siRNA) has been recognized to regulate the expression of genes and gained attention as a potential therapeutic reagent in many genetic diseases. The siRNA is a class of double-stranded, non-coding RNA molecules, usually about 20-25 base pairs long. By RNA interference pathway, the siRNA is either loaded onto RISC directly or utilizes a Dicer mediated process, thereby initiating the RNAi process via targeting mRNA cleavage and degradation. Based on the outstanding expertise and rich experience, Creative Biolabs has the expertise and ability in providing abundant siRNA products with the best quality to advance our global clients' projects.
Figure 1. Schematic of siRNA-mediated RNAi mechanism. (Maria, 2019)
Creative Biolabs is dedicated to establishing the most exquisite service platform for RNAi therapy. We have sophisticated equipment and highly experienced staff, which is able to provide you with custom siRNA services that allows for flexibility in experimental initiation. From the foremost project design to the final products, we implement stringent criteria to guarantee the reliability and quality. The siRNA with custom modifications is also available to ensure specificity and reduce off-target effects. A series of ready-to-use siRNA products have been developed in house and we also offer the right reagent to efficient siRNA transfection.
Features of Our Custom siRNA Products
- Complimentary designs and cost-effectiveness
- Sequence-specific silencing with high quality and specificity
- Comprehensive modifications are available upon request
- Flexible synthesis scales and custom services
We also provide custom siRNA synthesis service, producing highly pure siRNA in diverse amounts (nmol) and offer various combinations of sizes, modifications, and purifications for convenient online ordering.
If you are interested in our service, please contact us by E-mail and our team will get back to you as soon as possible.
Reference
- Raja, M.; et al. (2019). Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA. Asian Journal of Pharmaceutical Sciences, 14(5), pp.497-510.
