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Custom Exosomes Service for RNAi


Exosomes have emerged as novel gene delivery tools owing to their multiple advantages over conventional delivery systems for RNA interference (RNAi). Equipped with world-leading technology platforms and professional scientific staff, Creative Biolabs offers top-quality service in the development of exosome-mediated delivery system for RNAi. We are pleased to share our cutting-edge technology and extensive experience in custom exosome service to facilitate our clients’ research and project development.

Characteristics of Exosomes

Exosomes are nano-sized vesicles (40-120 nm in size) released by many cell types (including dendritic cells, T cells, B cells, mast cells, epithelial cells and tumor cells) in all body fluids (such as peripheral blood, malignant effusions, urine, and bronchoalveolar lavage fluid). They are key mediators that are involved in the communication between cells and facilitate the transfer of genetic information between distant cells. Exosomes are composed of lipids, proteins, and several types of RNAs which allow these vesicles to serve as important disease biomarkers. As exosomes naturally carry RNA (including shuttle RNA, mainly mRNA and microRNA) between cells, these particles might be useful in genetic cancer therapy to deliver therapeutic short interfering RNA (siRNA) to the target cells.

Exosomes Delivery System for RNAi

Custom Exosomes Service for RNAi

The great interest of using exosomes for siRNA delivery derives from the intrinsic ability of exosomes to shuttle small RNA molecules among different cells. A number of advantageous features, including high stability in circulation, intrinsic capacity to traverse biological barriers, potential targeting abilities, efficient cellular entry, lower immunogenicity and toxicity, enable exosomes to be a promising delivery system. Exosomes possess a lipid bilayer vesicular structure with an aqueous core and a lipophilic shell. This special structure enables exosomes to deliver both hydrophilic and hydrophobic payloads, which is quite desirable for the delivery of siRNA molecules. In addition, exosomes have an ideal particle size, making them possible to avoid rapid renal clearance and phagocytosis by the mononuclear phagocyte system. Exosomes are shown to be slightly negative charged, which explains their improved stability in blood circulation. Moreover, as natural biological delivery vehicles, exosomes are more compatible with the immune system and less likely to cause immune response and toxicity than artificially synthesized nanocarriers when used in vivo.

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Different strategies are employed to introduce siRNAs into human exosomes of various origins. The exosome siRNAs conjugations have been proved to be effective at causing post-transcriptional gene silencing in recipient cells, inducing massive reproductive cell death of recipient cancer cells. Our scientists have exploited an approach to target exosomes with specific peptides, and subsequently, load them with siRNA for targeted delivery.

The therapeutic potential of exosome-mediated siRNA delivery system has been demonstrated in vitro, which gives additional evidence of the ability to use human exosomes in RNAi-based gene therapy. Experienced in the development of exosome-mediated delivery system for RNAi, Creative Biolabs has perfected our technical pipelines to offer high-quality custom exosome service for RNAi. For more detailed information, please feel free to contact us or directly send us an inquiry.

For Lab Research Use Only, Not for Human or Animal Therapeutic Use.

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