Custom Nanoparticles Service
The mode change of nanoparticles used for RNAi molecule delivery is attributed to the unique advantages provided by nanoparticles compared to other carriers. One of the important advantages is the enhanced permeability and retention (EPR) effect, which enables nanocarriers to accumulate in tumors at much higher concentrations than normal tissues. On the basis of our understanding of the development of RNAi and delivery systems, Creative Biolabs is confident in providing you with comprehensive and high-quality services for RNAi.
What Are Nanoparticles?
Nanoparticles are particulate dispersions or solid particles with the particle size in the range of 10-1000 nm. They are the most common choice for the delivery of RNAi. Compared with other carriers, nanocarriers can protect RNAi molecules from enzymatic degradation and immune recognition, have higher transportation efficiency across the cell membrane, and can prevent excretion if the carrier size and surface coating are appropriate. Nanocarriers for RNAi can be divided into organic nanoparticles and inorganic materials. Drugs can be incorporated into organic nanoparticles by chemical bonding or physical embedding. Among inorganic nanocarriers, mesoporous silica nanoparticles (MSNs) are the most commonly used because of their unique properties, such as uniform mesopores, easy functionalization, biocompatibility, high specific surface area, large pore volume and biodegradability.
Figure 1. The destiny of synthetic siRNA-loaded nanoparticles with desirable structural and functional properties. (Chen, 2018)
Services
In recent years, the application of nanoparticles as gene carriers in RNAi has attracted extensive attention. Many studies have determined the effective application of RNAi delivered by diverse nanocarriers. In order to systematically regulate the immune system and allow it to cross the physiological barrier, delivery systems must be engineered to provide serum stability, offer high structural and functional tenability, reduce the interaction with non-target cells, enhance cell entry and escape, resist renal clearance, and produce low toxicity and immunogenicity.
At present, Creative Biolabs has a variety of nanoparticle systems to provide customized services for RNAi delivery. These systems include:
- Organic materials, such as liposomes and micelles
- Inorganic materials, such as carbon nanotubes, quantum dots, gold nanoparticles
Customized services combine our preclinical research and rich experience in nanoparticle synthesis and development can better serve RNAi delivery.
Features of Our Custom Nanoparticles
Our nanoparticles are designed in a modular manner, so that it is easy to switch out individual modules and incorporate custom modalities. To this end, nanocarriers are designed by selecting 1) a nanoparticle scaffolds, 2) a targeting ligands, and 3) a treatment modality. Our modular approach allows easy switching between therapeutic groups without modifying any other nanoparticle composition, which provides a convenient platform for comparative analysis of the therapeutic activity in vivo.
If you are interested in our services, please feel free to contact us.
Reference
- Chen, X., et al. (2018). RNA interference-based therapy and its delivery systems. Cancer and Metastasis Reviews. 37(1): 107-124.
