ImmunoArrayᵀᴹ Oligomannose Microarray (CAT#: NA-0726-FY39)

The Oligomannose Microarray is a high-sensitivity carbohydrate-binding matrix engineered to systematically map interactions with linear, branched, high-mannose, and phosphorylated sugar structures. Displaying 46 structurally well-defined oligomannose isomers immobilized across an 8- or 16-subarray configuration, this high-throughput tool resolves fine substrate specificities from minimal sample volumes in just a few hours. Serving as an essential platform for functional glycomics, it bridges a critical tool gap by enabling translational medicine researchers to decode how intricate mannose linkage codes govern endoplasmic reticulum protein quality control, lysosomal sorting, microbial pathobiology, and innate immune recognition via C-type lectin pathways.

Specifications
SizeMulti-array slide format featuring 8 or 16 identical sub-arrays per chip, enabling parallel multi-sample profiling. It accommodates a total of 46 distinct oligomannose structural configurations plus controls.
Throughput LevelHigh-throughput (enables the simultaneous analysis of 8 to 16 samples on a single chip, yielding reliable ligand-binding maps within just a few hours).
Arraying TechnologyMultiplex glycan microarray technology where 46 distinct oligomannose structures are orderly printed onto the sub-arrays of a solid slide surface; molecular binding interactions (such as the Galanthus nivalis lectin [GNA] binding model resolved via biotin-streptavidin-Cy3 chemistry) are captured and measured using a microarray slide scanner at a 532 nm wavelength.
Quality ControlIntegrated positive controls (e.g., PC1) are embedded within each sub-array layout to demonstrate expected target-ligand binding signals, verifying correct printing alignment, orientation, and overall assay validation.
Features46 Distinct Isomeric Targets: Features closely related linear, branched, and phosphorylated configurations with defined linkages to precisely chart fine substrate specificities. High Sensitivity & Specificity: Highly optimized to differentiate closely related oligomannose isomers and trace phosphorylation markers. Flexible 8 or 16 Sub-Array Format: Designed with 16 or 8 identical testing blocks per slide to facilitate streamlined multi-variable comparative screening. Ultra-low Sample Volume: Employs a simplified, highly efficient micro-assay format requiring only minimal biological sample sizes. Customization & Service Support: Fully customizable (allowing users to select specific oligomannose compositions for custom microarray formats) and available as a comprehensive analytical testing service.
Application FieldsBinding Specificity Evaluation: Mapping and defining the precise carbohydrate-binding preferences and fine sub-site specificities of mammalian or microbial oligomannose-binding proteins (such as GNA lectins) and target antibodies. Host-Pathogen Interaction & PAMP Research: Investigating microbial pathogen-associated molecular patterns (PAMPs) and host immune recognition; studying how bacterial adhesins (e.g., FimH on type 1 fimbriae of uropathogenic E. coli) anchor to host tissues, or how innate C-type lectin receptors (CLRs like DC-SIGN, L-SIGN, Dectin-2, and Langerin) trigger protective cascades. Cellular Quality Control Mechanisms: Exploring structural interactions involved in intracellular homeostatic transport, such as Mannose-6-Phosphate (Man-6-P) receptor-mediated lysosomal hydrolase trafficking and ER-associated protein folding/degradation quality control pathways. Interactome & Cellular Profiling: Exploring binding activities with diverse biological targets including viruses, bacteria, whole cells, cell lysates, serum, and extracellular vesicles.
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