NAA Services for Anti-5-HT
Alzheimer’s disease (AD) is the most common cause of severe memory loss and cognitive deterioration in the elderly, while 5-HT plays an important role in neuronal development and differentiation. Having accumulated abundant experience, Creative Biolabs is a leading service provider in the AD diagnosis market and provides custom-specific natural autoantibody (NAA) services for our customers. With the techniques’ development and expertise introduction, we now offer a wide range of customized NAA services and products for anti-5-HT antibodies.
Background of Anti-5-HT Antibody
5-HT, also known as serotonin, plays an important regulatory role in all kinds of immune responses mediated by T cells, B cells, and macrophages through direct and indirect ways. 5-HT is usually considered as a typical neurotransmitter. It plays a regulatory role in the immune system. 95% of 5-HT in peripheral circulation are synthesized by pheochromocytes in the gastrointestinal tract and then released to blood. 5-HT participates in the autoimmune reaction by mediating the activation of T and B cells in several pathways.
Fig.1 Schematic representation of 5-HT in the terminal and synapse. (Vinkers, 2010)
Autoantibodies to 5-HT (anti-5-HT-Abs) are present in the serum of patients with psychiatric disorders. The occurrence of anti-5-HT-Abs could indicate autoantibodies to the receptor, which in turn could result in a disturbance of this receptor. Antibody reactivity is also associated with the autoimmune process of the central nervous system (CNS).
The Role of Anti-5-HT in Alzheimer's Disease
AD is a progressive neurodegenerative disorder manifested by a progressive decline in cognitive functions. The most promising AD biomarkers in platelets are 5-HT and lipids. 5-HT plays an important role in cognition, at the same time, a combination of disturbances in cholinergic and serotonergic functions may play a role in cognitive impairment in AD. It has been reported that platelets’ dense granules are the major storage site for 5-HT in the blood, similar to its vesicular storage in neurons, triggered the idea of using platelets as an experimental system in AD. AD patients always show significantly reduced platelet 5-HT levels; furthermore, lower 5-HT content in patients with Subjective Cognitive Impairment was associated with a higher AD-cerebrospinal fluid (CSF) biomarker burden. Thus, 5-HT seems to be a good candidate biomarker for early AD.
Fig.2 5-HT receptors and amyloid protein precursor processing. (Butzlaff, 2016)
What We Can Do About NAA?
Equipped with our well-established platforms and experienced scientists, we can provide comprehensive NAA services, from NAA detection, NAA profiling, to NAA epitope mapping. A wide spectrum of NAA products is available for your choice.
Features of Our Anti-5-HT Services Including but Not Limited to
- Different NAA detection methods with high accuracy and specificity
- One-stop pipeline to save your time or energy
- High efficiency without numerous repeats
- Best after-sale service
Armed with extensive experience and advanced platform, Creative Biolabs provides a full range of NAA services against 5-HT marker for the diagnosis of early AD. If you are interested in the service we provide, please feel free to contact us for more detail and information.
References:
- Vinkers, C.H.; et al. Stress-induced hyperthermia: the serotonin system and anxiety. Open Pharmacology Journal.2010, 4: 15-29.
- Butzlaff, M.; Ponimaskin, E. The role of serotonin receptors in Alzheimer’s disease. Opera Medica et Physiologica. 2016, (1).
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