NAA Services for Anti-Tau Antibodies
As an acknowledged antibody service provider, Creative Biolabs offers various NAA services to help our customers obtain ideal laboratory test results contributing to your research and projects successfully. Currently, we offer high-quality anti-Tau antibodies marker services for Alzheimer's disease diagnosis and therapy. Our professional technical scientists can not only save your valuable time but also provide highly sensitive and qualified products and solutions for our clients all over the world.
Background of Anti-Tau Antibodies
Tau proteins (also referred to as τ proteins) are a kind of neuronal proteins encoded by MAPT that promote the assembly and stability of microtubules. Tau proteins mainly distribute in neurons of the central nervous system (CNS) and are less common elsewhere, but are also expressed at undetectable levels in CNS astrocytes and oligodendrocytes. Defective tau proteins are or inappropriate stabilization microtubules can result in the pathologies and dementias of the nervous system, such as Alzheimer's disease (AD) and Parkinson's disease. In addition, tau proteins play a significant role in the establishment and maintenance of neuronal polarity since the hyper-phosphorylated tau proteins are the main component of neurofibrillary tangles. Anti-Tau antibodies are autoantibodies specifically against tau proteins, mainly IgM and IgG isotypes, produced in an autoimmune response and neurodegenerative process. Detection of these tau autoantibodies might provide a sight of AD diagnosis.
Fig.1 Proposed modes of action of anti-tau antibodies. (Congdon, 2018)
The Role of Anti-Tau Antibodies in Alzheimer's Disease
Alzheimer's disease (AD) is an age-related neurodegenerative disorder which recently has been suggested to be a kind of autoimmune disease. A variety of autoantibodies have been detected from patients with AD, among which anti-tau antibody is a low-level antibody. It has been demonstrated that autoantibodies of IgM isotype against phosphorylated-tau in the serum of AD patients increased significantly compared with the healthy controls. Consistent results have been obtained by the detection of anti-tau autoantibodies in cerebrospinal fluid of AD patients. Furthermore, the phosphorylated tau levels in AD patients were much higher in the saliva, an easily available body fluid sample relative to cerebrospinal fluid, than that in healthy human saliva. All these results indicate that salivary tau proteins and serum tau autoantibodies, especially anti-phosphorylated-tau IgM antibodies, can be used as a valuable biomarker in AD disease evaluation, more importantly, which also provide a direction for AD therapy.
Fig.2 Tau-related therapeutic targets. (Congdon, 2018)
Choose Us for Your NAA Projects!
Creative Biolabs offers a variety of NAA products, NAA services, and related applications with our first-class platforms and experienced scientists, including but not limited to NAA detection, NAA profiling, NAA affinity measurement, NAA epitope mapping, and paratope mapping.
Creative Biolabs is a well-recognized leader in the field of NAA diagnosis and detection. We are dedicated to the development of innovative NAA services to help increase the accuracy of the clinical diagnosis and to support clinicians in the effective management of different types of diseases. Please contact us for more information if you are interested in our services.
Reference:
- Congdon, E.E.; Sigurdsson, E.M. Tau-targeting therapies for Alzheimer disease. Nature Reviews Neurology. 2018, 14(7): 399-415.
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