NAA Services for Anti-M2 Receptor Antibodies

Creative Biolabs is a world leader in the field of NAA services. Based on our years of experience and first-class platform, we are confident in offering the best and most suitable natural autoantibodies (NAA) detection and analysis. Here we provide anti-M2 receptor antibodies marker services for diseases diagnosis and therapy. Our experienced scientists will take part in every step of your program to accelerate your project development.

Background of Anti-M2 Receptor Antibodies

M2 receptor is a muscarinic acetylcholine receptor encoded by the CHRM2 gene in humans. The M2 receptors play an important role in the heart by slowing the heart rate down to normal sinus rhythm. They also can reduce the contractile forces of the atrial cardiac muscle, and the conduction velocity of the atrioventricular node (AV node). Autoantibodies to M2 receptors are a class of abnormal antibodies produced by the immune system that attack M2 receptors mistakenly. Several reports have indicated that M2 receptor autoantibody, together with other related autoantibodies, linked to cardiac diseases such as myocarditis and dilated cardiomyopathy.

Fig.1 Thyroid hormone, autoantibodies activation, and inflammation act synergistically to develop atrial fibrillation in Grave disease. (Jia, 2015)

The Role of Anti-M2 Receptor Antibodies in Myocarditis

Myocarditis is an inflammation disease of the heart muscle, also referred to as inflammatory cardiomyopathy. The anti-M2 receptor antibodies have been demonstrated associated with the disease. Therefore, a synthetic peptide analogous of the human M2 receptor was used as an antigen to screen sera from patients with idiopathic dilated cardiomyopathy (DCM) and healthy blood donors. Obviously, the sera from patients with DCM can recognize the receptor peptide. Evidence also found that the antimuscarinic receptor-2 autoantibodies were associated with the anti-beta-adrenoceptor-1 autoantibodies in the myocarditis patients' sera. All of these data indicated that the anti-M2 receptor antibodies could be a useful biomarker during the diagnosis and treatment of myocarditis.

What We Can Do About NAA?

Creative Biolabs is one of the forward-looking antibody research institution and provider, leading the development of the antibodies while offering the best service to the customers around the world. We are pleased to provide high-quality NAA services to contribute to the success of your project. Our anti-M2 receptor antibodies marker services may help the diagnosis of myocarditis disease for our worldwide customers.

More importantly, at Creative Biolabs, a full range of NAA products is available for your choice. In addition, extensive NAA services are provided based on our first-rate platforms and abundant experience, including NAA detection, NAA profiling, NAA affinity measurement, NAA epitope mapping, and paratope mapping.

Features of Our Services

State-of-the-art platform
Prominent scientists
High efficiency and timely manner
Cost-effective services

If you are interested in the services we provide, please feel free to contact us for more detail and information.

Reference:

Jia, G.; Sowers, J.R. Autoantibodies of β-adrenergic and m2 cholinergic receptors: atrial fibrillation in hyperthyroidism. Endocrine. 2015, 49(2): 301-303.

For Research Use Only | Not For Clinical Use

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