NAA Services for Anti-Transglutaminase 2 Antibodies (ATG2A)

Creative Biolabs is an undisputed global leader in the customized natural autoantibody (NAA) services for various biomarkers of diversiform diseases. Here, we provide high-affinity anti-transglutaminase 2 (TG2) autoantibodies services for the diagnosis and therapy of disease. Our high-quality services will contribute greatly to the success of your project.

Background of Anti-Transglutaminase 2 Antibodies

Anti-transglutaminase antibodies (ATA) are a kind of autoantibodies against the transglutaminase protein. Antibodies play an important role in the immune system by detecting cells and substances, including foreign antigens (for example, viruses) and substances produced by the body (for example, cancer cells). If antibodies direct against these self-substances, they are called autoantibodies. Sometimes autoantibodies can mistakenly direct against healthy portions of the organism, leading to autoimmune diseases. Currently, ATA can be classified according to 2 different schemes: transglutaminase isoform and immunoglobulin reactivity subclass (IgA, IgG) toward transglutaminases.

The Role of ATG2A in NAA Associated Celiac Disease

Celiac disease is an inflammatory disorder, commonly caused by an incorrect immune response to ingested wheat gluten (consist of gliadin and glutenin) and related cereal proteins in genetically predisposed individuals, leading to villous atrophy, crypt hyperplasia and lymphocytic infiltration in the small intestine. Anti-TG2 antibodies, the specific marker of celiac disease, are deposited locally in the intestine primarily but they have also been found in liver, muscle and lymph nodes. Currently, the anti-TG2 antibody test is an important tool in the diagnosis of celiac disease. The test for anti-TG2/endomysial antibodies is based on the patient serum upon suspicion of celiac disease. If the patient is anti-TG2/endomysial IgA antibodies positive, or IgG antibody is positive but IgA is deficient, or in less common cases of negative serology but high clinical suspicion, then it is essential to perform an intestinal biopsy. Positive identification of the characteristic histologic abnormalities results in a presumptive diagnosis of celiac disease and institution of gluten-free diet. Clinical improvement of the diet would yield a definitive diagnosis.

Fig.1 Gluten modification: mechanism of anti-TG2 antibody production. (Paolella, et al., 2022)Fig.1 Gluten modification: mechanism of anti-TG2 antibody production.1

What Can We Do about NAA?

We offer all kinds of NAA services with our well-established platforms and experienced scientists, include NAA detection, NAA profiling, NAA affinity measurement, etc. A wide range of NAA products is available for your choice.

With the rapid development of the NAA market, natural autoantibodies have been extensively used for the diagnosis of a variety of disease. Creative Biolabs is committed to providing high-quality NAA detection and analysis services to contribute to the success of your project. Our experienced scientists can offer anti-transglutaminase 2 (TG2) antibodies marker services to help the diagnosis of celiac disease. If you are interested in the service we provide, please feel free to contact us for more detail and information.

Reference:

  1. Paolella, Gaetana, et al. "Type 2 transglutaminase in coeliac disease: A key player in pathogenesis, diagnosis and therapy." International Journal of Molecular Sciences 23.14 (2022): 7513.
For Research Use Only | Not For Clinical Use

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