Girentuximab

Cat

TAB-707

Product Overview

Recombinant chimeric antibody expressed in CHO binding to human CAIX. Girentuximab is a chimeric monoclonal antibody designed for the treatment of renal cell carcinoma.

Target

CAIX

Type

IgG1 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in WB, ELISA, IP, FC, FuncS, Neut, IF and most other immunological methods.

CAS

916138-87-9

Trade name

rencarex

Predicted N terminal

DVKLVESG

Molecular Weight

146.5 kDa

Purity

>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Size

1mg

Storage

Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Introduction

Girentuximab is a chimeric monoclonal antibody designed for the treatment of renal cell carcinoma.

Antigen Description

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

Function

carbonate dehydratase activity; lyase activity; metal ion binding; zinc ion binding;

Gene ID

768

Synonyms

CA9; carbonic anhydrase IX; carbonic anhydrase 9; CAIX; carbonic dehydratase; MN; RCC associated protein G250; pMW1; CA-IX; P54/58N; membrane antigen MN; carbonate dehydratase IX; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250;

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