Creative Biolabs has established custom membrane protein and membrane protein antibody production platforms for antibody discovery.
Membrane proteins, actually, are a kind of proteins acting as ion channels, receptors, and transporters, which enable the cells to transport environmental signals across the biological membranes. Membrane proteins can be classified into two categories, integral (intrinsic) and peripheral (extrinsic) membrane proteins—based on the nature of the membrane-protein interactions.
It has been proven that membrane proteins perform a wide range of functions in cell growth, cell-cell communication (signaling transduction), differentiation, flow of information, metabolism, and migration. Defects in some membrane proteins can lead to diseases, such as cancer, therefore, membrane proteins represent nearly 50% of the targets of therapeutic research. It is very difficult to study membrane proteins due to their naturally low expression levels, although, the study of the structures of membrane proteins is a hot-spot issue all over the world because this will help to better understand the functions of these membrane proteins. Creative Biolabs has many unparalleled expression systems to obtain high-yield and native conformational membrane proteins.
The low expression of membrane proteins, the prevalence of non-specific proteins, and the toxicity of target proteins during cell line selection have hampered the capacity of cell-based immunogens to elicit high-quality antibodies for many key membrane protein targets. To get around this obstacle, we created the MPAT™ platform.
Creative Biolabs provides monoclonal and polyclonal antibody production services using the Multiple Epitopes Antigen Designer (MEAD™) Platform. The main benefit of the MEAD™ platform is its high rate of success in producing high-affinity antibodies that can recognize proteins that are challenging to express, like ion channels, GPCRs, and other proteins that span multiple membranes.
Except for membrane protein production, Creative Biolabs can provide customized membrane protein antibody production services. Solubilization of the membrane protein immunogens with detergents may lead to major conformational changes, making their testing with monoclonal antibodies by immune blot and ordinary immunoprecipitation difficult. Using unique MPAT™ and MEAD™ technologies, Creative Biolabs specializes in membrane protein and its antibody production services. Please feel free to contact us for a detailed quote.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.