Creative Biolabs is a leading service provider that focuses on antibody engineering for research, diagnostic and therapeutic use. Our service portfolio includes antibody affinity maturation, antibody stability improvement, chimeric antigen receptor (CAR) construction, scFv/Fab construction and other antibody specialization and modification services.
Since the first hybridoma has been obtained, a kind of possibility has arisen to modify the antibody to enhance its functionality. During this decade, antibody has become a major class of new drugs to treat several disease indications including cancer and autoimmune diseases. As the foundation of many diagnostics and therapeutics, the specific antigen binding ability of antibodies is critical for variety purposes, such as expanding detection limits, extending dissociation half-life time, decreasing therapeutic dosages and increasing overall efficacy. Nevertheless, it is still beneficial to optimize these antibodies or antibody related molecules with respect to their activity.
Through modern molecular biology techniques, interested antibodies can be specific modified or engineered to suit the application. If the heavy- and light-chain sequences are determined, the interested antibody can be reconfigured into different isotypes or a variety of formats (scFv, Fab, sdAb, bispecific antibody, etc.) and other possible modification including affinity measurement, humanization, caninization and so on. One feasible way is done by sequencing and cloning the interested region of antibody and grafting this select region onto a suitable framework to construct a plasmid. The predicted antibody can then be produced by transient transfection using appropriate expression system, such as mammalian cells and E. coli strains. As a choice, antibody modification can also incorporate with phage or other display methods to obtain a much broader candidates or select the most ideal products for numerous applications. Notably, all these modification and manufacture can be perfectly implemented by Creative Biolabs who is a well-recognized expert in the field of antibody development and phage display technology.
Creative Biolabs has devoted to the field of antibody engineering for over decade and established a series of comprehensive platforms to integrate various antibody engineering services. With the extensive experience, abundant industry knowledge and advanced technical skills, our scientists are fully confident in accomplishing even the most challenging antibody engineering project.