Creative Biolabs is a leading service provider that focuses on antibody engineering for research, diagnostic and therapeutic use. Our service portfolio includes antibody affinity maturation, antibody stability improvement, chimeric antigen receptor (CAR) construction, scFv/Fab construction and other antibody specialization and modification services.
Since
the first hybridoma has been obtained, a kind of possibility has arisen to
modify the antibody to enhance its functionality. During this decade, antibody
has become a major class of new drugs to treat several disease indications
including cancer and autoimmune diseases. As the foundation
of many diagnostics and therapeutics, the specific antigen binding ability of
antibodies is critical for variety purposes, such as expanding detection
limits, extending dissociation half-life time, decreasing therapeutic dosages
and increasing overall efficacy. Nevertheless,
it is still beneficial to optimize these antibodies or antibody related molecules
with respect to their activity.
Through
modern molecular biology techniques, interested antibodies can be specific
modified or engineered to suit the application.
If the heavy- and light-chain sequences are determined, the interested antibody
can be reconfigured into different isotypes or a variety of formats (scFv, Fab,
sdAb, bispecific antibody, etc.) and other possible modification including affinity
measurement, humanization, caninization and so on. One feasible way is done
by sequencing and cloning the interested region of antibody and grafting this
select region onto a suitable framework to construct a plasmid. The predicted
antibody can then be produced by transient transfection using appropriate
expression system, such as mammalian cells and E. coli strains.
As a choice, antibody modification can also incorporate with phage or other
display methods to obtain a much broader candidates or select the most ideal
products for numerous applications. Notably, all these modification and manufacture
can be perfectly implemented by Creative
Biolabs who is a well-recognized expert in the field of antibody
development and phage display technology.
Creative
Biolabs has devoted
to the field of antibody engineering for over decade and established a series
of comprehensive platforms to integrate various antibody engineering services.
With the extensive experience, abundant industry knowledge and advanced technical
skills, our scientists are fully confident in accomplishing even the most challenging antibody
engineering project.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.