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Membrane Protein Solubilization and Stabilization Reagents
Membrane proteins mediate processes that are fundamental for the flourishing of biological cells, playing critical roles in cellular function and therapeutic targets. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. One outstanding challenge is the difficulty in preparing a sufficient amount of these membrane proteins so as to be able to generate the functional antibody and conduct functional assays.
Membrane Protein Solubilization
Common Membrane Protein Solubilization Reagents
Detergent
Cat
|
Product Name
|
CAS Number
|
CMC in H2O
|
MPD0025K
|
n-Octyl-β-D-Glucopyranoside (OG)
|
29836-26-8
|
0.53%
|
MPD0041K
|
n-Dodecyl-β-D-Maltopyranoside (DDM)
|
69227-93-6
|
0.0087%
|
MPD0044K
|
n-Decyl-β-D-Maltopyranoside (DM)
|
82494-09-5
|
0.087%
|
MPD0070K
|
Lauryl Maltose Neopentyl Glycol (LMNG)
|
1257852-96-2
|
0.001%
|
MPD0092K
|
CHAPS
|
75621-03-3
|
0.49%
|
MPD0182K
|
GDN
|
1402423-29-3
|
0.0021%
|
MPD0204K
|
Octaethylene Glycol Monododecyl Ether (C12E8)
|
3055-98-9
|
0.0048%
|
Phospholipids
Cat
|
Product Name
|
Classifications
|
CAS Number
|
MPL0001K
|
DPPC
|
Phosphatidylcholine (PC)
|
63-89-8
|
MPL0002K
|
DSPC
|
Phosphatidylcholine (PC)
|
816-94-4
|
MPL0005K
|
DOPC
|
Phosphatidylcholine (PC)
|
4235-95-4
|
MPL0006K
|
POPC
|
Phosphatidylcholine (PC)
|
26853-31-6
|
MPL0007K
|
DAPC
|
Phosphatidylcholine (PC)
|
61596-53-0
|
MPL0009K
|
DSPE
|
Phosphadylethanolamine (PE)
|
1069-79-0
|
MPL0089K
|
DSPG
|
Phosphatidylglycerol (PG)
|
200880-42-8
|
MPL0092K
|
DLPG
|
Phosphatidylglycerol (PG)
|
322647-27-8
|
MPL0093K
|
DSPA
|
Phosphatidic Acid (PA)
|
108321-18-2
|
MPL0096K
|
DLPA
|
Phosphatidic Acid (PA)
|
108321-06-8
|
MPL0097K
|
DOPA
|
Phosphatidic Acid (PA)
|
108392-02-5
|
MPL0098K
|
DPPS
|
Phosphatidylserine (PS)
|
145849-32-7
|
MPL0099K
|
DOTAP
|
Cationic Lipids
|
132172-61-3
|
Nanodiscs
Cat
|
Product Name
|
Species
|
Tag
|
Nanodiscs Size
|
MPN0001K
|
MSP1E3D1, His-
|
Streptomyces kanamyceticus
|
His tag at N-terminus
|
12.9 nm in diameter
|
MPN0002K
|
MSP1D1, His-
|
Microbial
|
His tag at N-terminus
|
9.7 nm in diameter
|
MPN0016K
|
MSP1D1 ∆H5, tag-free
|
Human
|
Tag-free
|
7-8 nm in diameter
|
MPN0017K
|
MSP1D1, tag-free
|
Mouse
|
Tag-free
|
9-10 nm in diameter
|
MPN0024K
|
MSP1E3D1, tag-free
|
Human
|
Tag-free
|
12-14 nm in diameter
|
MPN0025K
|
MSP2N2, His
|
Human
|
His tag
|
17 nm in diameter
|
Polymer
Cat
|
Product Name
|
Molecular Formula
|
Formula Weight
|
MPP010K
|
Amphipol A8-35
|
C6.2H10.3O1.35N0.65Na0.35)~72
|
9 kDa
|
MPP011K
|
Poly (Maleic Anhydride-alt-1-Decene) substituted with 3-(Dimethylamino) Propylamine
|
(C19H36O3N2)n
|
18,500.00
|
MPP012K
|
Poly (Maleic Anhydride-alt-1-Tetradecene) substituted with 3-(Dimethylamino) Propylamine
|
(C23H44O3N2)n
|
12,000.00
|
MPP013K
|
Poly (Maleic Anhydride-Alt-1-Octadecene) substituted with 3-(Dimethylamino) Propylamine
|
(C27H52O3N2)n
|
39,000-65,000
|
MPP014K
|
Biotinylated Amphipol A8-35
|
C6.5H11.225O1.375N0.75Na0.325)~72
|
9.3 kDa
|
MPP015K
|
Poly (Maleic Anhydride-alt-1-Decene) substituted with 3-(Dimethylamino) Propylamine and Biotin ethylene diamine
|
(C19H36O3N2)n.(C26H43O5N4S)m
|
18.5 kDa
|
MPP016K
|
Non-Ionic Amphipol A8-35
|
C7H15O4SN (C31H54O15N2)n
|
7000-35000g/mol
|
Application of Different Membrane Protein Solubilization Forms
Detergent form
|
Liposome form
|
Nanodisc form
|
Polymer form
|
-
X-ray Protein crystallization
-
Solution-state NMR
-
Enzyme kinetics
-
Protein engineering and
-
mutagenesis studies
-
Drug screening
-
Drug target discovery
-
Diagnostic application
|
-
Electron microscopy
-
Solid-state NMR
-
Transport assays
-
Therapeutic application
-
Drug screening
-
Protein-protein interaction experiment
-
Small molecule or drug target discovery
|
-
Immunization & antibody selection
-
Studies of protein-protein/protein-lipid/protein-ligand/protein-additive interactions
-
Membrane protein delivery
-
Studies of membrane protein conformation dynamics
-
Discovery of small-molecule drugs
|
-
Protein structure with Cryo-EM
-
Protein-lipid interaction
|
All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.
Membrane Protein Solubilization and Stabilization Reagents