Membrane proteins mediate processes that are fundamental for the flourishing of biological cells, playing critical roles in cellular function and therapeutic targets. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. One outstanding challenge is the difficulty in preparing a sufficient amount of these membrane proteins so as to be able to generate the functional antibody and conduct functional assays.
Detergent-solubilization is a routine procedure for membrane protein isolation in most cases. We provide unique solubilization
reagents to screen for the best outcome.
Cat | Product Name | CAS Number | CMC in H2O |
MPD0025K | n-Octyl-β-D-Glucopyranoside (OG) | 29836-26-8 | 0.53% |
MPD0041K | n-Dodecyl-β-D-Maltopyranoside (DDM) | 69227-93-6 | 0.0087% |
MPD0044K | n-Decyl-β-D-Maltopyranoside (DM) | 82494-09-5 | 0.087% |
MPD0070K | Lauryl Maltose Neopentyl Glycol (LMNG) | 1257852-96-2 | 0.001% |
MPD0092K | CHAPS | 75621-03-3 | 0.49% |
MPD0182K | GDN | 1402423-29-3 | 0.0021% |
MPD0204K | Octaethylene Glycol Monododecyl Ether (C12E8) | 3055-98-9 | 0.0048% |
Phospholipids are one of the most frequently used formats for stabilizing membrane proteins, which is well applicable to immunization, assays, and diverse usages.
Cat | Product Name | Classifications | CAS Number |
MPL0001K | DPPC | Phosphatidylcholine (PC) | 63-89-8 |
MPL0002K | DSPC | Phosphatidylcholine (PC) | 816-94-4 |
MPL0005K | DOPC | Phosphatidylcholine (PC) | 4235-95-4 |
MPL0006K | POPC | Phosphatidylcholine (PC) | 26853-31-6 |
MPL0007K | DAPC | Phosphatidylcholine (PC) | 61596-53-0 |
MPL0009K | DSPE | Phosphadylethanolamine (PE) | 1069-79-0 |
MPL0089K | DSPG | Phosphatidylglycerol (PG) | 200880-42-8 |
MPL0092K | DLPG | Phosphatidylglycerol (PG) | 322647-27-8 |
MPL0093K | DSPA | Phosphatidic Acid (PA) | 108321-18-2 |
MPL0096K | DLPA | Phosphatidic Acid (PA) | 108321-06-8 |
MPL0097K | DOPA | Phosphatidic Acid (PA) | 108392-02-5 |
MPL0098K | DPPS | Phosphatidylserine (PS) | 145849-32-7 |
MPL0099K | DOTAP | Cationic Lipids | 132172-61-3 |
Nanodiscs aim at stabilizing membrane proteins in mimic lipid bilayers with a more dense environment that is even closer to the natural membrane environment.
Cat | Product Name | Species | Tag | Nanodiscs Size |
MPN0001K | MSP1E3D1, His- | Streptomyces kanamyceticus | His tag at N-terminus | 12.9 nm in diameter |
MPN0002K | MSP1D1, His- | Microbial | His tag at N-terminus | 9.7 nm in diameter |
MPN0016K | MSP1D1 ∆H5, tag-free | Human | Tag-free | 7-8 nm in diameter |
MPN0017K | MSP1D1, tag-free | Mouse | Tag-free | 9-10 nm in diameter |
MPN0024K | MSP1E3D1, tag-free | Human | Tag-free | 12-14 nm in diameter |
MPN0025K | MSP2N2, His | Human | His tag | 17 nm in diameter |
Polymer technique can solubilize hydrophobic membrane proteins without detergent, meanwhile maximally preserving native confirmation and bioactivity.
Cat | Product Name | Molecular Formula | Formula Weight |
MPP010K | Amphipol A8-35 | C6.2H10.3O1.35N0.65Na0.35)~72 | 9 kDa |
MPP011K | Poly (Maleic Anhydride-alt-1-Decene) substituted with 3-(Dimethylamino) Propylamine | (C19H36O3N2)n | 18,500.00 |
MPP012K | Poly (Maleic Anhydride-alt-1-Tetradecene) substituted with 3-(Dimethylamino) Propylamine | (C23H44O3N2)n | 12,000.00 |
MPP013K | Poly (Maleic Anhydride-Alt-1-Octadecene) substituted with 3-(Dimethylamino) Propylamine | (C27H52O3N2)n | 39,000-65,000 |
MPP014K | Biotinylated Amphipol A8-35 | C6.5H11.225O1.375N0.75Na0.325)~72 | 9.3 kDa |
MPP015K | Poly (Maleic Anhydride-alt-1-Decene) substituted with 3-(Dimethylamino) Propylamine and Biotin ethylene diamine | (C19H36O3N2)n.(C26H43O5N4S)m | 18.5 kDa |
MPP016K | Non-Ionic Amphipol A8-35 | C7H15O4SN (C31H54O15N2)n | 7000-35000g/mol |
Detergent Form | Liposome Form | Nanodisc Form | Polymer Form |
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All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.