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Anti-idiotype Antibody Production Services

Overview Types of Anti-ID Abs Anti-ID Ab Development ServicesServices Highlight Case Study Applications

Anti-idiotype Antibodies (anti-ID Abs) Overview

Anti-ID Abs are Abs that can recognize the variable region of an Ab and produce specific binding. Anti-ID Abs play a vital role in the development of drugs. On the one hand, anti-ID Abs can serve as a valuable reference for immunogenicity analysis. On the other hand, they are also vital tools for pharmacokinetic/pharmacodynamics (PK/PD) studies. Creative Biolabs offers unparalleled anti-ID Abs production and downstream testing services. We are committed to developing anti-ID Abs with high specificity, high affinity and high sensitivity from different species, such as rabbit, chicken, cow, sheep, mice, rats and humans to meet your unique needs.

1-5-anti-idiotype-antibody-production-services-1.jpg Fig.4 The structure of antibody. (Creative Biolabs Original)

Types of Anti-ID Abs

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Antigen Blocking Type Antigen Non-blocking Type Drug-target Complex Specific Abs
Antigen binding: Inhibitory / neutralizing Antigen binding: Non-inhibitory Antigen binding: Non-inhibitory
Applications: Detection of free Ab drug and partially bound antibody drugs Applications: Detection of total Ab drug Applications: Detection of bound Ab drug only

Anti-ID Ab Development Summary

Services Delivery Lead time
Anti-ID Rabbit Polyclonal Ab Preparation Service Purified Ab;
Ab QC Report
3.5 months
Anti-ID Mouse Monoclonal Ab Preparation Service Compete and/or non-compete purified Abs; Ab QC Report; Hybridoma cell line 5 months
Phage Displayed Library Screening of Anti-ID Ab Purified Ab; Plasmid; Strain; Ab sequences, Ab QC Report 4 months
Development of Immunogenicity Detection Kits Kit; Manual; R&D report 3.5 months
Development of PK Detection Kits Kit; Manual; R&D report 3.5 months

Featured Anti-ID Ab Services

Featured Technology Platforms

Hybridoma Platform Phage Display & Antibody Library Polyclonal Antibody Development
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Fig.8 Hybridoma platform. (Saeed, et al., 2017)
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Fig.9 Phage display & antibody library. (Wu, et al., 2016)
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Fig.10 Polyclonal antibody development. (Garcia-Calvo, et al.,2020)

Services Highlight

Case Study - Anti-ID antibody development

Case A

Ab Structure Analysis. (Creative Biolabs Original)Fig. 1 Anti-ID monoclonal Ab has no cross reaction with isotype human IgG and total human IgG.

Case B

Antigen blocking type. (Creative Biolabs Original)Fig. 2 Competition ELISA of Anti-ID monoclonal Ab.

Case C

Fig.3 Antigen non-blocking type. (Creative Biolabs Original)Fig. 3 Anti-ID polyclonal Ab-good specificity, little cross-reactivity with human IgG.

Applications

Ab drug-target complex specific. (Creative Biolabs Original)
PK and PD Analysis of Ab Drugs
Anti-ID monoclonal Ab has no cross reaction with isotype human IgG and total human IgG. (Creative Biolabs Original)
Immunogenicity study of Ab drugs
Competition ELISA of Anti-ID monoclonal Ab. (Creative Biolabs Original)
Preclinical research of therapeutic Abs
Anti-ID polyclonal Ab -good specificity, little cross-reactivity with human IgG. (Creative Biolabs Original)
Controls in Ab blocking assays
PK and PD Analysis of Ab Drugs. (Creative Biolabs Authorized)
Controls in ligand binding neutralizing assays
Immunogenicity study of Ab drugs. (Creative Biolabs Authorized)
Suitable for high-throughput detection of specific Ab drug content in the blood

If you are interested in our anti- ID Ab production services, please contact us in time to get a detailed quotation.

References

  1. Saeed, Abdullah FUH, et al. "Antibody engineering for pursuing a healthier future." Frontiers in microbiology (2017): 495.
  2. Wu, Chien-Hsun, et al. "Advancement and applications of peptide phage display technology in biomedical science." Journal of biomedical science 23.1 (2016): 1-14.
  3. Garcia-Calvo, Eduardo, et al. "From polyclonal sera to recombinant antibodies: A review of immunological detection of gluten in foodstuff." Foods 10.1 (2020): 66.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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