Creative Biolabs can offer various antibody labeling services to help our customers obtain their very own labeled antibodies. Our technical scientists can not only save the valuable time, but also provide highly stable and qualified products for our clients all over the world.
Labelled antibodies have become essential research tools in the biological researches as well as diagnostics. Since antibodies have been widely used to detect and quantify antigens, a large amount of demands of labeled antibody have generated. Currently, a variety kinds of labels are available to be used, such as organic dyes, fluorescent proteins, colored particles, enzymes and other potential bioactive molecules which have unique properties to produce measurable signal under the appropriate conditions. For instance, horseradish peroxidase (HRP) and alkaline phosphatase (ALP) can be attached as signal-generating molecules via the specific reaction they catalyze, while fluorescent labels are detected by microscopy equipment under excitation at specific wavelengths.
With appropriate strategy, various labels can be linked to specific antibodies. In general, four modes of labelling strategies can be used to the antibody molecules, which include linkages occur through charged amino acids, carbohydrate moieties, sulfhydryl groups and tyrosine residues. In detail, charged amino acids are abundant and wildly distributed on the outer surface of antibodies, however the modification may interfere with the function of antibody; carbohydrate moieties are generally found on the highly glycosylated Fc region which are distant from the antigen recognition site, while required more attention to the oxidation steps; sulfhydryl groups contains on cysteine residues, the modification may not damage the specificity but may affect the avidity; tyrosine residues can be specifically iodinated as radioactive label, although has fallen out of favor. Due to the different advantages and shortcomings, choosing or combining suitable strategies are critical to build up an ideal labeled antibody. Because of the ability to image multiple antigens in a single cell or tissue section, labelled antibodies has allowed many elegant and valuable experiments to be performed and expanded their applications to a variety of immunoassays, such as flow cytometry, ELISA, western blotting and immunohistochemistry. Nowadays, Creative Biolabs is able to provide novel labelled antibodies suitable for customers’ particular application needs.
As an acknowledged biotechnology provider, Creative Biolabs is noted for its first-class services, strictly controlled products and customer oriented philosophy. By leveraging years of antibody labeling expertise, our scientists are able to provide a wide selection of services for both research and commercial use with the best quality at the most competitive price.
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