With state-of-the-art facilities and enriched experience in antibody engineering, Creative Biolabs has developed excellent CreMap™ epitope mapping & discovery platform to provide customers professional technical services in a time- and cost-efficient manner.
Epitope, or antigenic determinant, is typically a segment on an antigen that can be recognized by antibodies or T cells for triggering the specific immune responses. Epitope mapping is the process of identifying the binding sites of antibodies (or TCRs) on target antigens, which helps discover the new therapeutics, vaccines, and diagnostics. Identifying epitopes also gives a clue about the mechanism of binding to antibodies or T cell receptors. In most cases, epitope mapping is performed with monoclonal antibodies (mAbs).
Fig.1 Predicted B cell epitopes of Human papillomavirus type 16 major late capsid protein L1.
The techniques determining the potent epitopes (both T cell epitopes and B cell epitopes) have been greatly improved by the application and development in immunology for the past years. And these robust techniques could help you to:
Creative Biolabs' outstanding research group has developed the CreMap™ B Cell Epitope Mapping Platform and CreMap™ T cell Epitope Mapping Platform based on the professional knowledge and enriched experiences. We provide excellent epitope mapping services for our clients based on our advanced platforms.
CreMap™ B Cell Epitope Mapping Platform
The B cell epitopes are the binding sites of an antigen recognized by the corresponding antibodies. Based on the different binding characteristics, B cell epitopes contain two categories: linear epitopes and conformation epitopes. The linear epitopes are continuous sequences of amino acid on peptide chains, whereas the conformation epitopes act as sequence discontinuous amino acid chains but spatially adjacent.
Our expert group in Creative Biolabs has developed an advanced B cell epitope mapping platform, which contains several advanced technologies for mapping both conformational and linear epitopes in a high-throughput and efficient way. Read more…
CreMap™ T Cell Epitope Discovery Platform
In the CreMap™ T cell epitope discovery platform, Creative Biolabs has developed an exceptional MHC-peptide binding assay for determining the potent binding sites of the T cell with effective approaches. Compared with other ineffective and time-consume strategies, this platform provides a cost-effective solution for your epitope detection when you are attempting to design a peptide vaccine or develop a protein drug to certain diseases. Read more…
Over the past few years, Creative Biolabs has been providing best-in-class epitope mapping service by our excellent CreMap™ platform, aiming to guide your epitope mapping and discovery research. If you are interested in our service, pleasecontact us for more detail information.