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Membrane Protein Production Service

Membrane proteins, which constitute over thirty percent of all proteins in human genome, play a vital role in many cellular functions like materials transportation, signal transduction, intercellular recognition ligand-receptor binding, cell adhesion, etc. As such, they represent the absolute majority (over 60%) of current drug targets. Due to their low natural abundance and highly complicated structure (partially or completely associated with plasma membrane), obtaining recombinant membrane protein products with native conformation and bio-activity has always been a challenging issue.

Membrane protein (Creative Biolabs)

Creative Biolabs has integrated multiple cutting-edge technologies and established a powerful Magic™ membrane protein production platform.

Cell-based Membrane Protein Expression and Purification (Creative Biolabs)

The Cell-based Membrane Protein Expression and Purification is the most commonly used approach for membrane proteins production. For membrane proteins, it can be problematic as for adequate expression levels, correct membrane insertion, and native confirmation preservation. Using our proprietary vector designs and special protocols, we have successfully generated a broad spectrum of targets.

Cell-free Membrane Protein Expression and Purification (Creative Biolabs)

Cell-free Membrane Protein Expression and Purification platform which is derived from modified cellular extracts, exert unique beneficial feature for expressing many challenging or "difficult" target, especially membrane proteins or toxic proteins. This highly robust, efficient and controllable system can also be directly reconstituted with lipids or nanodiscs, avoiding the use of detergent.

Virus Like Particles (VLPs) (Creative Biolabs)

Virus Like Particles (VLPs) are multiprotein structures that mimic the organization and conformation of authentic native viruses but lack the viral genome (non-infectious). They are widely applied in vaccinology, immunology, and virology. Currently, we offer VLP construction and purification service in various systems, including bacterial, insect, mammalian, etc. PTMs can also be incorporated.

Membrane Protein Solubilization and Stabilization (Creative Biolabs)

Most membrane proteins cannot be solubilized or stabilized in aqueous solutions without the aid of any amphipathic materials. One of the most common difficulties in handling membrane proteins is the choice of the amphipathic materials. Amphipathic materials can play an indispensable role in the extraction, solubilization, stabilization, characterization, functionalization, and activation of membrane proteins.

Equipped with multiple leading technologies and abundance expertise, Creative Biolabs is confident in delivering satisfactory membrane protein products with our first-class professional service. We provide quite flexible options about expression, solubilization/reconstitution, and purification as well as characterization (such as binding assays, functional assays). A pilot study is strongly recommended to gather some preliminary data, and then we can move to further optimizations and scaling-up stage. Please feel free to contact us for a detailed quote.

Membrane protein Production Service (Creative Biolabs)


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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