visilizumab

DESCRIPTION	CATALOG #	SIZE	PRICE
Anti-CD3E Therapeutic Antibody (Nuvion)	TAB-714	1mg	Please Inquiry

Product Detail

Product Overview: Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD3 receptor. Visilizumab is a humanized monoclonal antibody. It is being investigated for use as an immunosuppressive drug in patients with ulcerative colitis and Crohn's disease.

Immunogen: The details of the immunogen for this antibody are not available.

Applications: Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.

Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Background

Introduction: Visilizumab is a humanized monoclonal antibody and is being investigated for use as an immunosuppressive drug in patients with ulcerative colitis and Crohn's disease.

Antigen Description: The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.

Function: SH3 domain binding; T cell receptor binding; protein heterodimerization activity; protein kinase binding; receptor activity; receptor signaling complex scaffold activity; receptor signaling protein activity; transmembrane signaling receptor activity;

Synonyms: CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell antigen receptor complex, epsilon subunit of T3; T3E; TCRE; FLJ18683;