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Libivirumab (TAB-147)

DESCRIPTION CATALOG # SIZE PRICE
Anti-HBV Therapeutic Antibody TAB-147 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to HBV. Libivirumab is a human monoclonal antibody directed against the hepatitis B virus.
  • Target
  • Hepatitis B surface antigen
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • HBV
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in WB, ELISA, IP, FC, FuncS, Neut, IF and most other immunological methods.
  • CAS
  • 569658-79-3
  • Specificity
  • Tested positive against native HBV antigen.
  • Protein Construction
  • Immunoglobulin G, anti- (hepatitis B surface antigen)(human monoclonal 17.1.41 heavy chain), disulfide with human monoclonal 17.1.41 kappa-chain, dimer
  • Predicted N terminal
  • H chain: QVKLLES; L chain: ELVMTQ
  • Molecular Weight
  • 149040
  • Purity
  • >95%, by SDS-PAGE with silver staining, under reducing conditions.
  • Size
  • 1mg
  • Storage
  • Store at -20°C. Avoid multiple freeze/thaw cycles.

BACKGROUND

  • Introduction
  • This is a human monoclonal antibody directed against the hepatitis B virus.
  • Antigen Description
  • HBV (HBV) infection induces a disease state which manifests itself in a variety of ways, characterized by the extent of liver damage, inflammation and viral persistence. HBV infection is also associated with a 100 fold increased risk of hepatocellular carcinoma and currently infects over 250 million people worldwide. HBV has a partially double stranded 3.2 kilobase DNA genome which contains four open reading frames. One of these encodes a 154 amino acid protein called the HBx protein. HBx has been shown to be a transcriptional transactivator of both viral and cellular promoters. Lacking a DNA binding domain and nuclear localization signal, HBx is believed to exert transcriptional activity through protein protein interaction.
  • Keywords
  • HBsAg; Hep B surface antigen; Hepatitis B Virus major surface antigen; Hepatitis B virus S antigen; Large envelope protein; Large surface protein; LHB; Major surface antigen

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