Belimumab

Cat

TAB-030

Product Overview

Recombinant monoclonal antibody to Human BLyS. Belimumab (trade name Benlysta, previously known as LymphoStat-B) is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). B cells are responsible for part of the normal immune response, and also for the over-aggressive immune response in autoimmune diseases like systemic lupus erythematosus (SLE).

Target

BLyS

Type

IgG1 - lambda

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.

CAS

356547-88-1

Trade name

benlysta, lymphostat-b

Specificity

Tested positive against native human antigen

Protein Construction

ImmunoglobulinG1, anti-(human cytokine BAFF) (human monoclonal LymphoStat-B heavy chain),disulfide with human monoclonal LymphoStat-B l-chain, dimer

Purity

Purity >95% by SDS-PAGE.

Size

1mg

Storage

At -20°C for one year.

Antigen Description

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.

Function

cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding;

Gene ID

10673

Synonyms

TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; TNFSF20; tumor necrosis factor ligand superfamily member 13B; BAFF; BLYS; CD257; TALL 1; TALL1; THANK; delta BAFF; Delta4 BAFF; B-lymphocyte stimulator; B-cell-activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20; DTL; ZTNF4; TALL-1;

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