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iodine (124I) girentuximab (TAB-H43)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CA9 Therapeutic Antibody (REDECTANE) TAB-H43 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Chimeric antibody to Human CA9. The drug candidate REDECTANE® (INN: 124I-Girentuximab) is based on an antibody and is being developed for the pre-surgical diagnosis of clear cell Renal Cell Cancer. REDECTANE® is the radioactively labelled form of the antibody Girentuximab. The monoclonal antibody Girentuximab binds specifically to a protein structure on the cell surface of malignant tumour cells. This protein structure, called Carbonic anhydrase IX (also CA-IX, MN or G250 antigen) is found on over 90 % of clear cell renal cell carcinomas, but not on normal renal tissue.
  • Type
  • IgG1 - kappa
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, IHC and most other immunological methods.
  • CAS
  • 953400-68-5
  • Trade name
  • redectane
  • Specificity
  • CA9 (carbonic anhydrase IX, CAIX, MN, G250) [Homo sapiens]
  • Purity
  • Purity >95% by SDS-PAGE.

BACKGROUND

  • Antigen Description
  • This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined.
  • Function
  • carbonate dehydratase activity; lyase activity; metal ion binding; zinc ion binding;
  • Synonyms
  • CA9; carbonic anhydrase IX; carbonic anhydrase 9; CAIX; carbonic dehydratase; MN; RCC associated protein G250; pMW1; CA-IX; P54/58N; membrane antigen MN; carbonate dehydratase IX; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250;

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