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Taplitumomab paptox (TAB-174)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD19 Therapeutic Antibody TAB-174 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to CD19. Taplitumomab paptox is a mouse monoclonal antibody designed for the treatment of cancer The antibody itself, taplitumomab, is linked to the protein PAP, an antiviral from Phytolacca americana, a species of pokeweed. This is reflected by the 'paptox' in the drug's name.
  • Target
  • CD19
  • Type
  • IgG1 - kappa
  • Immunogen
  • Mouse CD19-expressing K562 human erythroleukemia cells
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, ICC and most other immunological methods.
  • CAS
  • 235428-87-2
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G1,anti-(human CD19 (antigen)) (mouse monoclonal B43 g1-chain), disulfide with mouse monoclonal B43 k-chain, dimer, disulfide withprotein PAP (pokeweed antiviral) (9CI)
  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
  • Function
  • receptor signaling protein activity;
  • Synonyms
  • CD19; CD19 molecule; CD19 antigen; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4; B4; CVID3; MGC12802;

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