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Recombinant Rat antibody to Human CD3E. Ertumaxomab (trade name Rexomun) is a rat-murine hybrid monoclonal antibody designed to treat some types of cancer. It is a so-called trifunctional antibody which works by linking T-lymphocytes and macrophages to the cancer cells.
IgG2a / G2b
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
CD3E (CD3 epsilon) [Homo sapiens] ;
Trifunctional antibody.immunoglobulin G2a, anti-(human neu (receptor)) (mouse monoclonal 2502A/TP-A-02/TPBs03 heavy chain), disulfide with mouse monoclonal2502A/TP-A-02/TPBs03 light chain, disulfide with immunoglobulin G2b anti-(human CD3 (antigen)) (rat monoclonal 26/II/6-1.2/TPBs03 heavy chain),bidisulfide with rat monoclonal 26/II/6-1.2/TPBs03 light chain
>95.0% as determined by analysis by SDS-PAGE.
CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.
SH3 domain binding; T cell receptor binding; protein heterodimerization activity; protein kinase binding; receptor activity; receptor signaling complex scaffold activity; receptor signaling protein activity; transmembrane signaling receptor activity;