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Polatuzumab vedotin (TAB-897)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD79B Therapeutic Antibody TAB-897 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant humanized antibody expressed in CHO binding to human CD79B. Polatuzumab Vedotin is an anti-CD79b antibody-drug conjugate (ADC), and is composed of a monoclonal antibody (MAb), a stable linker, and the cytotoxic auristatin, and it is designed to selectively bind to CD79b while minimizing cytotoxic effects on hematologic cells that do not express CD79b.
  • Target
  • CD79B
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
  • CAS
  • 1313206-42-6
  • Predicted N terminal
  • EVQLVESG
  • Molecular Weight
  • Approximately 150 kDa
  • Purity
  • >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

BACKGROUND

  • Introduction
  • Polatuzumab Vedotin is an anti-CD79b antibody-drug conjugate (ADC), and is composed of a monoclonal antibody (MAb), a stable linker, and the cytotoxic auristatin, and it is designed to selectively bind to CD79b while minimizing cytotoxic effects on hematologic cells that do not express CD79b.
  • Antigen Description
  • Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
  • Function
  • transmembrane signaling receptor activity;
  • Synonyms
  • CD79B; CD79b molecule, immunoglobulin-associated beta; CD79B antigen (immunoglobulin associated beta) , IGB; B-cell antigen receptor complex-associated protein beta chain; B29; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta); IGB; AGM6;

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