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perakizumab (TAB-H57)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IL17A Therapeutic Antibody TAB-H57 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Humanized (from mouse) antibody to Human IL17A. Perakizumab (INN) is a humanized monoclonal antibody designed for the treatment of arthritis. It binds to IL17A and acts as an immunomodulator.
  • Type
  • IgG1 - kappa
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in WB, IF, IP, Neut, FuncS, ELISA, FC and most other immunological methods.
  • CAS
  • 89957-37-9
  • Specificity
  • IL17A (interleukin 17A, IL-17A) [Homo sapiens]
  • Protein Construction
  • gamma1 heavy chain (1-452) [humanized VH (Homo sapiens IGHV3-7*01 (90.80%) – (IGHD) – IGHJ4*01) [8.8.15] (1-122) – Homosapiens IGHG1*01 CH2 L1.3>A (239), L1.2>A (240) (123-452)], (225-215') – disulfide withkappa light chain (1'-215') [humanized V-KAPPA (Homo sapiens IGKV1 -16*01 (82.10%) – IGKJ2*01) [6.3.10] (1'-108') – Homo sapiensIGKC*01 (109'-215')]; (231-231":234-234") – bisdisulfide dimer
  • Purity
  • >95.0% as determined by analysis by RP-HPLC.

BACKGROUND

  • Antigen Description
  • The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis
  • Function
  • cytokine activity;
  • Synonyms
  • IL17A; interleukin 17A; CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); interleukin-17A; cytotoxic T lymphocyte associated protein 8; IL 17; IL 17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); IL17; CTLA8; IL-17; IL-17A;

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