Onartuzumab

Cat

TAB-190-F(P)

Product Overview

Recombinant monoclonal antibody Fragment Fab to Met. Onartuzumab is a humanized monoclonal antibody designed for the treatment of cancer.

Target

Met(c-Met)

Type

Fab / Fc - G1 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

E. coli

Applications

Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.

CAS

1133766-06-9

Specificity

Tested positive against native human antigen.

Protein Construction

Immunoglobulin G1, anti-(human scatter factor receptor kinase)(human-mouse monoclonal MetMAb heavy chain), disulfide with human-mouse monoclonal MetMAb kappa-chain, disulfide with human-mouse monoclonal MetMAb heavy chain hinge region-CH2-CH3 domain-containing fragment

Predicted N terminal

H chain: EVQLVES; L chain: DIQMTQS

Molecular Weight

99146

Purity

>95.0% as determined by analysis by RP-HPLC.

Size

1mg

Storage

At -20°C for one year.

Antigen Description

Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.

Function

ATP binding; hepatocyte growth factor-activated receptor activity; nucleotide binding; protein binding; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity;

Gene ID

4233

Synonyms

MET; met proto-oncogene (hepatocyte growth factor receptor); hepatocyte growth factor receptor; HGFR; RCCP2; SF receptor; HGF receptor; oncogene MET; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase; AUTS9; c-Met;

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