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Recombinant monoclonal antibody to SOST. Blosozumab binds SOST, a negative regulator of osteoblast activity. Blocking SOST activity can lead to increased bone density.
IgG4 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
Tested positive against native human antigen.
Immunoglobulin G4, anti-(human sclerostin) (human-Mus musculus monoclonal heavy chain), disulfide with human-Mus musculus monoclonal Kappa-chain, dimer
Predicted N terminal
H chain: QVQLVQS; L chain: DIQMTQS
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
heparin binding; protein binding; transcription factor binding;