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Recombinant monoclonal antibody to Human TAG72. Indium (111In) satumomab pendetide (trade name OncoScint CR103) is a mouse monoclonal antibody which is used for cancer diagnosis. The antibody itself, satumomab, is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111.
The details of the immunogen for this antibody are not available.
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, WB and most other immunological methods.
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
This monoclonal antibody can be attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111 and binds selectively to cell-surface TAG-72 expressed on colorectal tumors.
The majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for TAG72. About 60% of carcinoma patients express TAG72 in their sera. TAG72 is reportedly useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas.
CA 72.4; TAG 72; Tumor associated Glycoprotein 72; OncoScint CR103; Satumomab Pendetide