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Satumomab Pendetide (TAB-002)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human TAG72 Therapeutic Antibody (OncoScint CR103) TAB-002 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to Human TAG72. Indium (111In) satumomab pendetide (trade name OncoScint CR103) is a mouse monoclonal antibody which is used for cancer diagnosis. The antibody itself, satumomab, is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111.
  • Target
  • TAG72
  • Type
  • IgG1
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, WB and most other immunological methods.
  • CAS
  • 138955-26-7
  • Trade name
  • oncoscint cr103
  • Specificity
  • Tested positive against native human antigen
  • Protein Construction
  • Immunoglobulin G1 (mouse monoclonal B72.3 anti-human glycoprotein TAG-72), disulfide with mouse monoclonal B72.3 light chain, dimer
  • Predicted N terminal
  • H Chain: QVQLQQSL Chain: DIQMTQS
  • Purity
  • >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Size
  • 1mg
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

BACKGROUND

  • Introduction
  • This monoclonal antibody can be attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111 and binds selectively to cell-surface TAG-72 expressed on colorectal tumors.
  • Antigen Description
  • The majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for TAG72. About 60% of carcinoma patients express TAG72 in their sera. TAG72 is reportedly useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas.
  • Keywords
  • CA 72.4; TAG 72; Tumor associated Glycoprotein 72; OncoScint CR103; Satumomab Pendetide

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