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Placulumab (TAB-254)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human TNF Therapeutic Antibody TAB-254 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to TNF. Placulumab is a human monoclonal antibody designed for the treatment of inflammatory diseases
  • Target
  • TNF
  • Type
  • [V-kappa]2 - Fc
  • Immunogen
  • Full length native protein (purified) (Human).
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in WB, FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
  • CAS
  • 945781-29-3
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin (V-kappa)2-Fc gamma1, anti-[Homo sapiens TNF (tumor necrosis factor, TNF superfamily member 2, TNFSF2, TNFalpha, TNFA)], Homo sapiens monoclonal antibody
  • Predicted N terminal
  • H chain: DIQMTQS
  • Molecular Weight
  • 78700
  • Purity
  • >95.0% as determined by analysis by RP-HPLC.
  • Size
  • 1mg
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

BACKGROUND

  • Antigen Description
  • Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
  • Function
  • cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding;
  • Synonyms
  • TNF; tumor necrosis factor; TNFA, tumor necrosis factor (TNF superfamily, member 2); DIF; TNF superfamily; member 2; TNF alpha; TNFSF2; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2; TNFA; TNF-alpha;

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