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Recombinant monoclonal antibody to TNF. Placulumab is a human monoclonal antibody designed for the treatment of inflammatory diseases
[V-kappa]2 - Fc
Full length native protein (purified) (Human).
Suitable for use in WB, FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Tested positive against native human antigen.
Immunoglobulin (V-kappa)2-Fc gamma1, anti-[Homo sapiens TNF (tumor necrosis factor, TNF superfamily member 2, TNFSF2, TNFalpha, TNFA)], Homo sapiens monoclonal antibody
Predicted N terminal
H chain: DIQMTQS
>95.0% as determined by analysis by RP-HPLC.
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding;