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Recombinant Humanized (from mouse) Antibody binds selectively to Human CD22, expressed in Chinese Hamster Ovary cells(CHO)
Humanized (from mouse) IgG4 - kappa
Human tonsil lymphocytes
Suitable for use in FuncS, IF, Neut, ELISA and most other immunological methods.
Tested positive against native antigen.
Immunoglobulin G4, anti-(human CD22 (antigen)) (human-mouse monoclonal G544 heavy chain), disulfide with human-mouse monoclonal G544 Kappa-chain, dime
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling.