Anti-CD40LG Antibody

Cat

MOM-18027

Product Overview

Recombinant Humanized (from mouse) Antibody is bind to Human CD40L, expressed in Chinese Hamster Ovary cells(CHO)

Target

CD40L

Type

Humanized (from mouse) IgG1 - kappa

Immunogen

Animals were immunized with D1.1 cells.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.

Specificity

Tested positive against native antigen.

Protein Construction

Immunoglobulin G1, (anti-human CD40 ligand) (human-mouse monoclonal 5c8 gamma 1-chain), disulfide with human-mouse monoclonal 5c8 kappa-chain, dimer

Predicted N terminal

H Chain: QVQLVQS; L Chain: DIVLTQS

Purity

Purity >95% by SDS-PAGE.

Storage

4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Antigen Description

Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

Function

CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding;

Gene ID

959

Keywords

0

Synonyms

CD40LG; CD40 ligand; HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome; T B cell activating molecule; TNF related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; CD40-L; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; IGM; IMD3; HIGM1; T-BAM; TNFSF5;

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