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Recombinant Chimeric (mouse/human) Antibody Fab Fragment binds selectively to Human GD3 ganglioside, expressed in E. coli
Fab Fragment based on Chimeric (mouse/human) IgG1 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Tested positive against native antigen.
Predicted N terminal
H chain: EVQLVES; L Chain: DIQMTQS
Purity >95% by SDS-PAGE.
At -20°C for one year.
This is a chimeric monoclonal antibody being developed for the treatment of malignant melanoma.
Almost all melanomas, astrocytomas, a proportion of sarcomas, a small number of carcinomas, some nevi, as well as normal melanocytes express GD3 antigen. It is one of the most important markers for malignant melanoma. Antibodies to the GD3 ganglioside can induce partial remission of tumor growth in animals as well as in Humans via enhancement of cytotoxic and proliferative response of lymphocytes.