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Recombinant Mouse Antibody is against Human ICAM-1, expressed in Chinese Hamster Ovary cells(CHO)
Mouse Fab' - G2a
Tissue / cell preparation (Human). (Burkitt's lymphoma cell line RAJI).
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
Tested positive against native antigen.
Immunoglobulin G 2a (human monoclonal BI-RR-1 anti-human antigen CD 54), disulfide with mouse monoclonal BI-RR-1 light chain, dimer, reaction product with alpha-(2-carboxyethyl)-ω-methoxypoly(oxy-1,2-ethanediyl)
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
At -20°C for one year.
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.